5.09721

1α,25-Dihydroxy Vitamin D3

InSolution, ≥99%

• 别名: InSolution Vitamin D3, 1α, 25-Dihydroxy-, 1,25-(OH)₂-D₃
• 经验公式（希尔记法）: C₂₇H₄₄O₃
• 分子量: 416.64
• 分類程式碼代碼: 12352205
• NACRES: NA.21

属性

• 品質等級: 200
• 化驗: ≥99% (HPLC)
• 形狀: liquid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 儲存溫度: −70°C

说明

一般說明

Active hormonal form of vitamin D, formed by the renal 1-hydroxylation of 25-(OH)D₃. Has immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, which are an animal model of human autoimmune diabetes. Induces reversible hydrolysis of the sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca²⁺ and phosphate transport and mobilizes Ca²⁺ from bone. Involved in cellular differentiation, carcinogenesis, and insulin secretion.

應用

• Evaluation system for cell-permeable CYP3A4 inhibitory activity using 1α,25-dihydroxy-vitamin D(3)-induced intestinal cell lines.: Ueno et al. developed an evaluation system for cell-permeable CYP3A4 inhibitory activity utilizing 1α,25-dihydroxy-vitamin D3-induced intestinal cell lines. This system helps in screening for CYP3A4 inhibitors, which are critical in drug metabolism and interaction studies (Ueno et al., 2021).

生化／生理作用

Primary Target
vitamin D receptor

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

外觀

A 1 mM (50 ug/112 µL) solution of Vitamin D3, 1α, 25-Dihydroxy- (Cat. No. 679101) in DMSO.

重構

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

其他說明

Semizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA95, 15412.
Hannun, Y.A. 1994. J. Biol. Chem.269, 3125.
Mathieu, C., et al. 1994. Diabetologica37, 552.
Thomasset, M. 1994. Pathol. Biol.42, 163.
Horton, W.E., Jr., et al. 1991. J. Biol. Chem.266, 24804.
Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun.176, 1020.
Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun.176, 1189.
Wakasugi, M., et al. 1991. Prostaglandins42, 127.
Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun.166, 916.
Simpson, R.U., et al. 1989. J. Biol. Chem.264, 19710.
DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem.52, 411.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: 188.6 °F - (refers to pure substance)
• 閃點（°C）: 87 °C - (refers to pure substance)