506153

p38 MAP Kinase Inhibitor IV

The p38 MAP Kinase Inhibitor IV, also referenced under CAS 1638-41-1, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 别名: p38 MAP Kinase Inhibitor IV, 2,2ʹ-Sulfonyl-bis-(3,4,6-trichlorophenol), MT4
• 经验公式（希尔记法）: C₁₂H₄Cl₆O₄S
• CAS号: 1638-41-1
• 分子量: 456.94
• MDL编号: MFCD00397032
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥95% (HPLC)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; desiccated (hygroscopic); protect from light
• 颜色: light yellow
• 溶解性: DMSO: 4.5 mg/mL
• 运输: ambient
• 储存温度: 2-8°C
• SMILES字符串: [S](=O)(=O)(c2c(c(cc(c2O)Cl)Cl)Cl)c1c(c(cc(c1O)Cl)Cl)Cl
• InChI: 1S/C12H4Cl6O4S/c13-3-1-5(15)9(19)11(7(3)17)23(21,22)12-8(18)4(14)2-6(16)10(12)20/h1-2,19-20H
• InChI key: AKUKHICVNCCQHN-UHFFFAOYSA-N

说明

一般描述

A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC₅₀ = 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 µM) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 µM respective inhibitor).

包装

Packaged under inert gas

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Liu, Y.C., et al. 2007. Biochem. Biophys. Res. Commun.352, 656.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable