401477

IκB Kinase Inhibitor Peptide, Cell-Permeable

The IκB Kinase Inhibitor Peptide, Cell-Permeable controls the biological activity of IκB Kinase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• 别名: IκB Kinase Inhibitor Peptide, Cell-Permeable, Ac- AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂, Ac-AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂
• 经验公式（希尔记法）: C₁₃₈H₂₂₉N₃₇O₄₅S
• 分子量: 3158.58
• 分類程式碼代碼: 12352202
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: lyophilized
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 溶解度: PBS, pH 7.4: 1 mg/mL
• 運輸包裝: wet ice
• 儲存溫度: −20°C

说明

一般說明

A 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence fused to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells (<50 µg/ml) and prevents NF-κB activation. Supplied as a trifluoroacetate salt.

A 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence, linked to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IkB kinases (IKK) in RAW 264.7 cells (<50 μg/ml) and prevents NF-κB activation.

生化／生理作用

Cell permeable: no

Primary Target
LPS-induced IκB degradation by IKK in RAW 264.7 cells

Product does not compete with ATP.

Reversible: no

Target IC₅₀: <50 µg/ml for inhibiting LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells and prevents NF-κB activation

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

序列

Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ser-Gly-Leu-Asp-Ser-Met-Lys-Asp-Glu-NH₂

外觀

Supplied as a trifluoroacetate salt.

重構

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Swaroop, N., et al. 2001. Pharm. Res.18, 1631.
Traenckner, E.B., et al. 1995. EMBO. J.14, 2876.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable