400087
HIF-2α翻译抑制剂
The HIF-2α Translation Inhibitor, also referenced under CAS 882268-69-1, controls the biological activity of HIF-2α. This small molecule/inhibitor is primarily used for Cell Structure applications.
别名:
HIF-2α翻译抑制剂, 缺氧诱导因子-2α翻译抑制剂,甲基-3-(2-(氰基(甲磺酰基)亚甲基)肼基)噻吩-2-羧酸盐,HIF抑制剂II
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About This Item
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品質等級
化驗
≥95% (sum of two isomers)
形狀
solid
製造商/商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
amber
溶解度
DMSO: 5 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
一般說明
通过增强IRP1(铁调节蛋白1)与HIF-2α mRNA 5′ UTR处的IRE(铁反应元件)区域的结合来抑制细胞HIF-2α信息翻译的细胞渗透性噻吩腙化合物,否则对HIF-2α mRNA的转录或HIF-2α mRNA和蛋白的稳定性没有影响。已显示可降低仅表达2α种低氧诱导因子同工型的786-O细胞(终浓度为5-10 µM)中HIF-2α和HIF-2α靶基因(包括Glut-1,IGFBP3和VEGF)的细胞蛋白水平。
包裝
用惰性气体包装
警告
毒性:标准处理(A)
重構
复溶后,等分并冷冻保存(-20°C)。储备溶液在-20°C下可稳定保存至多6个月。
其他說明
Zimmer, M., et al. 2008.Mol.Cell32, 838.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
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