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Merck
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文件

251700

Sigma-Aldrich

1,5-Dansyl-Glu-Gly-Arg Chloromethyl Ketone, Dihydrochloride

Effective irreversible inhibitor of uPA, Factor Xa, and urokinase.

别名:

1,5-DNS-GGACK, 2HCl

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About This Item

分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
desiccated

顏色

off-white

運輸包裝

ambient

儲存溫度

2-8°C

一般說明

Effective irreversible inhibitor of uPA, Factor Xa, and urokinase. Fluorophore allows direct monitoring of interactions of labeled enzyme. Does not inhibit tPA.

生化／生理作用

Cell permeable: no
Primary Target
UPA
Product does not compete with ATP.
Reversible: no
Target IC50: 100 nM for factor Xa

警告

Toxicity: Standard Handling (A)

重構

Following initial thaw, aliquot and refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.
Reconstitute at 1 mg/ml in 10 mM HCl. Dilute with physiological buffers just prior to use.

其他說明

Bajaj, S.P., et al. 1992. Proc. Natl. Acad. Sci. USA89, 152.
Bergmeyer, H.V. 1984. Methods Enzym. Anal. 5, 375.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Margaux R Audett et al.
Molecular biology of the cell, 33(1), ar1-ar1 (2021-10-28)
KNL1 is a large intrinsically disordered kinetochore (KT) protein that recruits spindle assembly checkpoint (SAC) components to mediate SAC signaling. The N-terminal region (NTR) of KNL1 possesses two activities that have been implicated in SAC silencing: microtubule (MT) binding and

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