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一般說明
IKKγ has been shown to play a critical role in NF-κB activation, as the regulatory subunit of IκB kinase, which phosphorylates inhibitors of NF-κB leading to their degradation. Upon cell stimulation, IKKγ can be modified by Lys-63-linked or linear polyubiquitination, both of which are suggested to play key roles in cell signalling, including NF-κB activation. One of the E3 ligases responsible for Lys-63-linked IKKγ polyubiquitination is TRAF6, which participates in several signalling pathways controlling immunity, skin development, osteoclast formation and brain functions.
應用
Ubiquitination Cascade Comoponent: Substrate
外觀
Purified using glutathione sepharose.
法律資訊
GenBank is a registered trademark of United States Department of Health and Human Services
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
訊號詞
Warning
危險聲明
危險分類
Skin Sens. 1
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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