219261

Catalase, Aspergillus niger

Catalase, Aspergillus niger, CAS 9001-05-2, is a native, long-acting, extremely stable form of catalase that is active over a wide pH range (pH 1 - 12).

• 别名: Catalase, Aspergillus niger
• CAS号: 9001-05-2
• EC 号: 1.11.1.6 (BRENDA, IUBMB)
• MDL编号: MFCD00081483
• UNSPSC代码: 12352202
• NACRES: NA.77

属性

• 质量水平: 100
• 描述: Merck USA index - 14, 1900
• 表单: lyophilized powder
• 比活: ≥10,000 units/mg protein; ≥4000 units/mg dry wt.
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; desiccated (hygroscopic)
• 颜色: green
• 溶解性: H₂O: 1 mg/mL
• 运输: wet ice
• 储存温度: −20°C
• SMILES字符串: O(CC)C(=O)c1ccc(cc1)O
• InChI: 1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3
• InChI key: NUVBSKCKDOMJSU-UHFFFAOYSA-N

说明

一般描述

Research area: Cell Signaling

Catalase, Aspergillus niger, is a native, long-acting, extremely stable form of catalase that is active over a wide pH range (pH 1 - 12). Composed of four protein subunits, each containing a heme group bound to its active site, it is one of the most important antioxidant enzymes present in almost all aerobic organisms.

应用

Catalase may be used in:

• Industrial applications for eliminating hydrogen peroxide, which is utilized as an oxidizing, bleaching, or sterilizing agent.
• Food industry and egg processing, often in conjunction with other enzymes.
• Food preservation methods in combination with glucose oxidase, where superoxide dismutase produces H2O2, which is subsequently eliminated by catalase.
• Preservation process, along with glucose oxidase.

生化/生理作用

Catalase is responsible for breaking down two hydrogen peroxide molecules into one oxygen molecule and two water molecules in a two-step reaction. It plays a crucial role in regulating the cellular level and catabolism of hydrogen peroxide which in turn shields the cells from oxidative damage. Its malfunctioning and deficiency is linked to various diseases, including vitiligo, diabetes mellitus, anemia, cardiovascular diseases, bipolar disorders, Wilson disease, certain dermatological disorders, Alzheimer′s disease, hypertension, and schizophrenia. Anomalies in catalase activity are related to acatalasemia or Takahara disease, a rare genetic disorder.

警告

Toxicity: Standard Handling (A)

单位定义

One unit is defined as the amount of enzyme that will decompose 1.0 µmol H₂O₂ per min at 30°C, pH 7.0.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Note: 1 KU = 1000 units

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形图: GHS08
• 警示用语：: Danger
• 危险声明: H334
• 预防措施声明: P261 - P284 - P501
• 危险分类: Resp. Sens. 1
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable