211875

Captopril

An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC₅₀= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC₅₀ = 11 µM).

• 别名: Captopril, [2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline, SQ-14225
• 经验公式（希尔记法）: C₉H₁₅NO₃S
• CAS号: 62571-86-2
• 分子量: 217.29
• MDL编号: MFCD00168073
• UNSPSC代码: 12352200

属性

• 质量水平: 100
• 方案: ≥98% (titration)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze
• 颜色: white to off-white
• 溶解性: water: 1 mg/mL
• 运输: ambient
• 储存温度: 2-8°C
• InChI: 1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
• InChI key: FAKRSMQSSFJEIM-RQJHMYQMSA-N

说明

一般描述

An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC₅₀= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA₄ hydrolase (IC₅₀ = 11 µM). Inhibits angiogenesis and slows the growth of experimental tumors in rats. Reported to inhibit apoptosis in human lung epithelial cells (IC₅₀ = ~ 320 nM).

An antihypertensive agent. Reversible and competitive inhibitor of LTA₄ hydrolase (IC₅₀ = 11 µM). Also a competitive inhibitor of angiotensin-converting enzyme (ACE). Inhibits angiogenesis and slows the growth of experimental tumors in rats.

生化/生理作用

Cell permeable: no

Primary Target
ACE

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 23-35 nM against angiotensin-converting enzyme (ACE); 11 µM against LTA4 hydrolase; ~ 320 nM inhibiting apoptosis in human lung epithelial cells

警告

Toxicity: Carcinogenic / Teratogenic (D)

其他说明

Uhal, B.D., et al. 1998. Am. J. Physiol.275, L1013.
Volpert, O.V., et al. 1996. J. Clin. Invest.98, 671.
Voors, A.A., et al. 1995. J. Cardiovasc. Risk2, 413.
Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
Kostis, J. 1988. Am. Heart J. 116, 1591.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形图: GHS08
• 警示用语：: Danger
• 危险声明: H341,H360F
• 预防措施声明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危险分类: Muta. 2 - Repr. 1B
• 储存分类代码: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable