200980-M
Bikinin
A cell-permeable nonsteroidal pyridinylamido compound that acts as an ATP-competitive inhibitor.
别名:
Bikinin, Arabidopsis GSK-3 Inhibitor, Arabidopsis SHAGGY-related Kinase Inhibitor, GSK-3-like Kinase BIN2 Inhibitor, 4-((5-Bromo-2-pyridinyl)amino)-4-oxobutanoic acid
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About This Item
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化驗
≥90% (HPLC)
形狀
solid
製造商/商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
white
溶解度
DMSO: 50 mg/mL
儲存溫度
2-8°C
InChI
1S/C9H9BrN2O3/c10-6-1-2-7(11-5-6)12-8(13)3-4-9(14)15/h1-2,5H,3-4H2,(H,14,15)(H,11,12,13)
InChI 密鑰
XFYYQDHEDOXWGA-UHFFFAOYSA-N
一般說明
A cell-permeable nonsteroidal pyridinylamido compound that acts as an ATP-competitive inhibitor against 7 of the 10 Arabidopsis thaliana GSK3′s, BIN2 & ASKα/ γ/ε/ζ/ι/θ, but not ASKβ/δ or three other Arabidopsis Ser/Thr kinases, AtMPK4, AtMPK6, and AtAURORA1. The inhibitory activity is plant species-selective, as Bikinin exhibits much reduced activity against human Gsk-3β, Aurora B, Aurora C (45.6%, 69.4%, and 42.8% inhibition, respectively, with 10 µM Bikinin), and little or no activity against 74 other human kinases, nor does it affect GSK-3β-mediated dorsoventral axis formation during Xenopus embryo development. Bikinin at 30 µM is shown to bypass brassinolide (BL) and BRI1 and effectively activate brassinosteroid (BR) signaling responses in Arabidopsis thaliana seedings, including decreased BES1 phosphorylation, increased hypocotyl length, long and bending petioles, blade-shaped, pale-green leaves, as well as reduced lateral root density.
警告
Toxicity: Standard Handling (A)
重構
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他說明
Rybel, B.D., et al. 2009. Chem. Biol.16, 594.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
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