176708

Angiostatin K1-3, Human, Recombinant, E. coli

Angiostatin K1-3 is a recombinant form expressed in E. coli as a single, non-glycosylated polypeptide chain of 259 amino acids. A specific inhibitor of endothelial cell growth and angiogenesis.

• 别名: Ang K1-3, K1-3, rHuAng K1-3
• UNSPSC代码: 12352203
• NACRES: NA.77

属性

• 重组: expressed in E. coli
• 质量水平: 100
• 方案: ≥95% (HPLC and SDS-PAGE)
• 表单: lyophilized powder
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; avoid repeated freeze/thaw cycles
• 溶解性: aqueous buffer containing 0.1% BSA: soluble; water: soluble
• 运输: wet ice
• 储存温度: −20°C

说明

一般描述

Recombinant, human angiostatin expressed in E. coli as a single, nonglycosylated polypeptide chain containing 259 amino acids. Represents a proteolytic fragment containing the first three kringle structures of plasminogen. Acts as a specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED₅₀=70 nM) relative to kringles 1-4 (ED₅₀=135 nm).

警告

Toxicity: Standard Handling (A)

外形

Lyophilized from 20 mM Sodium Acetate, 4% Mannitol, pH 5.5.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Cao, R., et al. 1999. Proc. Natl. Acad. Sci. USA96, 5728.
Cao, E., et al. 1997. J. Biol. Chem.272, 22924.
Sim, B.K., et al. 1997. Cancer Res.57, 1329.
Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun.236, 651.
O′Rieilly, M.S., et al. 1994. Cell79, 315.
Peterson, T.E., et al. 1990. J. Biol. Chem.265, 6104.
Forsgren, M., et al. 1987. FEBS Lett.213, 254.
Malinowski, D.P., et al. 1984. Biochemistry23, 4243.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 1