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生物源
human
品質等級
重組細胞
expressed in baculovirus infected Sf21 cells
分子量
Mw 67.2 kDa
製造商／商標名
Upstate®
技術
activity assay: suitable (kinase)
NCBI登錄號
UniProt登錄號
一般說明
N-terminal GST-tagged recombinant human B-Raf residues 416-end
Product Source: Expressed by baculovirus in Sf21 insect cells
應用
Research Category
Metabolism
Inflammation & Immunology
Metabolism
Inflammation & Immunology
Research Sub Category
Obesity
Metabolic Disorders
Osteoporosis
Arthritis
Obesity
Metabolic Disorders
Osteoporosis
Arthritis
生化／生理作用
Protein Target: B-Raf
Target Sub-Family: TKL
包裝
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-530M when ordering the 250 µg size.
品質
routinely evaluated by phosphorylation of MBP substrate in vitro
外觀
Glutathione agarose affinity chromatography
儲存和穩定性
6 months at -70°C
其他說明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Mathew J Garnett et al.
Cancer cell, 6(4), 313-319 (2004-10-19)
RAF proteins are components of a conserved signaling pathway that regulates cellular responses to extracellular signals. Despite over 20 years of research into the regulation and function of the RAF proteins, it was only realized recently that the B-RAF isoform
Vanessa C Gray-Schopfer et al.
Cancer metastasis reviews, 24(1), 165-183 (2005-03-24)
Melanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. If detected early, it is easily treated by surgical excision. However, once melanoma metastasises it is notoriously resistant to
Kathryn E Mercer et al.
Biochimica et biophysica acta, 1653(1), 25-40 (2003-06-05)
A recent report has shown that activating mutations in the BRAF gene are present in a large percentage of human malignant melanomas and in a proportion of colon cancers. The vast majority of these mutations represent a single nucleotide change
Stevan R Hubbard
Cell, 116(6), 764-766 (2004-03-24)
A study by Wan et al. in this issue of Cell demonstrates that the majority of oncogenic mutations in the B-Raf protein kinase result in increased catalytic activity, through disruption of the autoinhibited state of the kinase domain. Surprisingly, several
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