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生物源
mouse
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
TD77, monoclonal
物種活性
chicken, human, mouse
技術
immunohistochemistry: suitable (paraffin)
western blot: suitable
同型
IgG1
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
chicken ... Tln1(395194)
human ... TLN1(7094)
mouse ... Tln1(21894)
一般說明
Talin consisting of a 47-kDa N-terminal head domain (residues 1-433) and a 190-kDa
C-terminal rod domain (residues 434-2541), links integrins to the actin cytoskeleton.
C-terminal rod domain (residues 434-2541), links integrins to the actin cytoskeleton.
特異性
Expected cross-reactivity in mouse and chicken.
Recognizes Human Talin, and cross reacts with Mouse and chicken Talin. The epitope recognized by this antibody is located within the C-terminal region of the protein (residues 2269-2541), which also contains an F-actin binding site homologous to that in the yeast actin-binding protein SIa2p.
應用
Detect Talin using this Anti-Talin Antibody, C-terminus, clone TD77 validated for use in WB, IH(P).
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Talin in human GI track tissue.
品質
Evaluated by Western Blot in Jurkat cell lysates.
Western Blot Analysis: A 1:500 dilution of this lot detected Talin in 10 ug of Jurkat lysates.
Western Blot Analysis: A 1:500 dilution of this lot detected Talin in 10 ug of Jurkat lysates.
標靶描述
270 kDa
聯結
Replaces: MAB3264
外觀
Purified from Protein A Sepharose™ chromatography
Format: Purified
Purified immunoglobulin from Protein A Sepharose™ chromatography. Liquid in 0.02M PBS pH 7.6, 0.25 M NaCl containing 0.1% sodium azide.
儲存和穩定性
Maintain between 2 and 8°C for 1 year after date of receipt.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律資訊
Sepharose is a trademark of Cytiva
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Michèle Moes et al.
The Journal of biological chemistry, 282(23), 17280-17288 (2007-04-14)
Talin1 is a large cytoskeletal protein that links integrins to actin filaments through two distinct integrin binding sites, one present in the talin head domain (IBS1) necessary for integrin activation and a second (IBS2) that we have previously mapped to
Andreas Wortmann et al.
The Journal of biological chemistry, 286(49), 42303-42315 (2011-10-14)
Reciprocal interactions between Src family kinases (SFKs) and focal adhesion kinase (FAK) are critical during changes in cell attachment. Recently it has been recognized that another SFK substrate, CUB-domain-containing protein 1 (CDCP1), is differentially phosphorylated during these events. However, the
Yekaterina B Khotskaya et al.
Molecular carcinogenesis, 53(12), 1011-1026 (2013-09-04)
Metastatic dissemination is a multi-step process that depends on cancer cells' ability to respond to microenvironmental cues by adapting adhesion abilities and undergoing cytoskeletal rearrangement. Breast Cancer Metastasis Suppressor 1 (BRMS1) affects several steps of the metastatic cascade: it decreases
Michael C Schmid et al.
Nature communications, 13(1), 1768-1768 (2022-04-03)
Myeloid cells play key roles in cancer immune suppression and tumor progression. In response to tumor derived factors, circulating monocytes and granulocytes extravasate into the tumor parenchyma where they stimulate angiogenesis, immune suppression and tumor progression. Chemokines, cytokines and interleukins
Mayra Álvarez-Santos et al.
Journal of cellular biochemistry, 117(10), 2385-2396 (2016-03-13)
The extracellular domains of some membrane proteins can be shed from the cell. A similar phenomenon occurs with β1 integrins (α1β1 and α2β1) in guinea pig. The putative role of β1 integrin subunit alterations due to shedding in airway smooth
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