P-063

苯妥英标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• 经验公式（希尔记法）: C₁₅H₁₂N₂O₂
• CAS号: 57-41-0
• 分子量: 252.27
• 分類程式碼代碼: 41116107
• NACRES: NA.24

属性

• 等級: certified reference material
• 形狀: liquid
• 特點: Snap-N-Spike^®/Snap-N-Shoot^®
• 包裝: ampule of 1 mL
• 製造商／商標名: Cerilliant^®
• 濃度: 1.0 mg/mL in methanol
• 技術: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 應用: clinical testing
• 格式: single component solution
• 儲存溫度: −20°C
• SMILES 字串: O=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3
• InChI: 1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
• InChI 密鑰: CXOFVDLJLONNDW-UHFFFAOYSA-N
• 基因資訊: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

说明

一般說明

Phenytoin is an antiepileptic drug used in the prevention and treatment of seizures. This analytical reference standard is suitable as starting material for the preparation of calibrators and controls in phenytoin testing by GC/MS or LC-MS/MS. Phenytoin is sold under the trade name Dilantin^®.

應用

• Advanced Separation and Extraction of Anticonvulsants: Phenytoin solution is utilized in the fabrication of surface molecularly imprinted polymer membranes. This innovative method enhances the separation and extraction of phenytoin, phenobarbital, and lamotrigine, significantly improving the precision and efficiency of drug monitoring in clinical and research settings (Zhao et al., 2024).


• LC-MS/MS Quantification for Drug Delivery: A sensitive LC-MS/MS method has been developed for the quantification of phenytoin and its major metabolite. This method is applied to both intravenous and intranasal delivery systems, enhancing our understanding of the pharmacokinetics and effectiveness of phenytoin as an anticonvulsant medication (Prentice et al., 2022).


• Clinical Decision Support for Pharmacogenomics: Phenytoin is involved in the appraisal and development of evidence-based clinical decision support systems. This research integrates pharmacogenomic data to optimize perioperative drug use, providing tailored therapeutic strategies based on genetic profiles, particularly for managing epilepsy treatments (Borden et al., 2021).


• Electromembrane Extraction Technique: The development of an electromembrane extraction method followed by capillary electrophoresis for phenytoin determination in exhaled breath condensate. This technique offers a non-invasive approach for therapeutic drug monitoring, critical for ensuring effective seizure control in epilepsy patients (Seyfinejad et al., 2020).


• Drug Crystallization Inhibition: Research into the use of polymer nanogels as reservoirs for phenytoin has shown potential in inhibiting drug crystallization. This approach could revolutionize drug delivery systems by maintaining the stability and bioavailability of phenytoin, enhancing its therapeutic efficacy for treating neurological disorders (Li et al., 2019).

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Dilantin is a registered trademark of Warner-Lambert Co.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS02,GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H225,H301 + H311 + H331,H370
• 防範說明: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• 危險分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 標靶器官: Eyes,Central nervous system
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: 49.5 °F - closed cup
• 閃點（°C）: 9.7 °C - closed cup