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H-004

Supelco

氢吗啡酮标准液 溶液

1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C17H19NO3
CAS号:
466-99-9
分子量:
285.34
EC號碼:
200-659-6
MDL號碼:
MFCD00864214
分類程式碼代碼:
41116107
PubChem物質ID:
329815100
NACRES:
NA.24

等級

certified reference material

品質等級

300

形狀

liquid

包裝

ampule of 1 mL

製造商／商標名

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

濃度

1 mg/mL in methanol

技術

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

應用

forensics and toxicology

形式

single component solution

儲存溫度

−20°C

SMILES 字串

CN1CC[C@@]23[C@H]4CCC(=O)[C@@H]2Oc5c(O)ccc(C[C@@H]14)c35

InChI

1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1

InChI 密鑰

WVLOADHCBXTIJK-YNHQPCIGSA-N

基因資訊

human ... OPRM1(4988)

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一般說明

该认证参考标准品适合用作校准品或对照品的原材料，用于从法医分析、临床毒理学、止痛药处方监测到尿液药物测试和药物研究等各种 LC/MS 或 GC/MS 应用。 氢吗啡酮，商品名为Palladone和Dilaudid®，是一种强效的阿片类镇痛药。该药通常在医学上用作吗啡的替代品，用于治疗疼痛或作为止咳药治疗持续性支气管刺激引起的疼痛性咳嗽。

應用


  • 氟哌啶醇的定量分析：研究人员开发了一种灵敏的LC-MS/MS方法用于定量测定人血浆中氟哌啶醇，该方法以氟哌啶醇-D₄为内标物，并结合磷脂去除预处理以提高检测准确性（Zidekova et al., 2021）。

  • 毒理学研究中的自动测定：氟哌啶醇-D₄在曲美布汀及其代谢产物毒代动力学研究的自动化方法中的应用，证明了化合物在高通量法医毒理学中的作用（Larabi et al., 2015）。

  • 高通量药物监测：高通量固相萃取和涡轮离子喷雾（turbo ionspray ）LC-MS-MS法在血浆中氟哌啶醇测定中的应用，展示了氟哌啶醇-D₄作为改进生物分析流程的稳定同位素标记标准品的效率（Hempenius et al., 1999）。



法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Dilaudid is a registered trademark of Purdue Pharma L.P.

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H-004S

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訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

標靶器官

Eyes

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

49.5 °F - closed cup

閃點（°C）

9.7 °C - closed cup

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Brandon A Van Noord et al.
Journal of clinical anesthesia, 25(2), 146-149 (2013-01-22)
A 35 year old woman, 6 days after ileal neobladder construction, reported uncontrolled pain despite 33 mg hydromorphone via patient-controlled analgesia (PCA). Abdominal compartment syndrome was suspected based on worsening tachypnea, oxygen desaturation, and severe, prolonged ileus. Following emergent intubation
Alec B O'Connor et al.
Journal of opioid management, 8(6), 403-413 (2012-12-25)
The reasons providers choose one parenteral opioid over another are not well understood. The authors sought to determine why emergency department (ED) providers choose one parenteral opioid over another. In a cohort of ED patients who received intravenous morphine or
Martin E Hale et al.
Journal of opioid management, 8(5), 299-314 (2012-12-19)
This analysis was designed to assess the pooled safety and tolerability of once-daily hydromorphone extended release (ER) (OROS® hydromorphone ER) in opioid-naïve and opioid-tolerant patients with chronic cancer or noncancer pain. Safety results were pooled from 13 controlled and uncontrolled
Jessica R Barker et al.
Veterinary surgery : VS, 42(1), 79-84 (2012-12-12)
To evaluate efficacy of a topical epidural analgesia used alone, or in combination with hydromorphone, against a standard pain protocol for the 48 hours immediately after hemilaminectomy. Randomized, blinded, controlled, clinical trial. Dogs (n = 30) with thoracolumbar intervertebral disc disease
Leah C Stern et al.
Journal of the American Veterinary Medical Association, 241(3), 344-347 (2012-07-21)
To determine the frequency of postoperative vomiting in dogs undergoing routine orthopedic surgery that were treated with hydromorphone and whether that frequency would vary on the basis of administration route. Noncontrolled clinical trial. Animals-58 client-owned dogs with cranial cruciate ligament
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