推荐产品
等級
certified reference material
品質等級
形狀
liquid
特點
Snap-N-Spike®/Snap-N-Shoot®
包裝
ampule of 1 mL
製造商／商標名
Cerilliant®
濃度
100 μg/mL in methanol
技術
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
應用
clinical testing
clinical testing
形式
single component solution
儲存溫度
−20°C
SMILES 字串
CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C
InChI
1S/C21H30O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h10,15-18,24-25H,4-9,11H2,1-3H3/t15-,16-,17-,18+,19-,20-,21-/m0/s1
InChI 密鑰
LCZBQMKVFQNSJR-UJPCIWJBSA-N
一般說明
一种新的校准材料，适用于LC/MS在临床和诊断测试以及内分泌学中的应用。通过LC/MS在全血或血清中测量21-脱氧皮质醇，一种在皮质醇形成中的类固醇中间体，用于先天性肾上腺皮质增生（CAH）和其他肾上腺疾病的新生儿筛查。
應用
- 通过微内径超高效液相色谱-串联质谱法诊断先天性肾上腺增生症的类固醇分析: 本论文强调了使用先进色谱技术进行类固醇分析来诊断先天性肾上腺增生的重要性，重点介绍了21-脱氧皮质醇作为关键标志物的作用（Feng D et al., 2023）。
- 荷兰21-羟化酶缺乏症的二级检测：新生儿筛查试点研究: 本研究介绍了一种涉及21-脱氧皮质醇的二级检测方案，用于改善新生儿先天性肾上腺增生的筛查过程，研究证明了其在早期和准确诊断中的实用性（Stroek K et al., 2021）。
法律資訊
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相關產品
产品编号
说明
价格
氢化可的松-D4标准液 CRM 溶液, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
11-脱氧皮质醇-D5标准液 CRM, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
17α-羟孕酮-13C3标准液 溶液, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
訊號詞
Danger
危險分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
標靶器官
Eyes
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
49.5 °F - closed cup
閃點（°C）
9.7 °C - closed cup
其他客户在看
Vânia Tonetto-Fernandes et al.
Journal of pediatric endocrinology & metabolism : JPEM, 21(5), 487-494 (2008-07-29)
21-Hydroxylase deficiency (21OHD) is the commonest form of congenital adrenal hyperplasia, while 11betaOHD represents 5% of cases. Although both result from mutations in distinct genes, cases of 'apparent' combined 21OHD and 11betaOHD (AC21,11OHD) have been occasionally reported. A 6 year-old
Surface-activated chemical ionization ion trap mass spectrometry in the analysis of 21-deoxycortisol in blood.
Simone Cristoni et al.
Rapid communications in mass spectrometry : RCM, 18(12), 1392-1396 (2004-06-03)
J Fiet et al.
Annals of clinical biochemistry, 31 ( Pt 1), 56-64 (1994-01-01)
21-deoxycortisol (21-DF) is a steroid of strictly adrenal origin formed by the 11-hydroxylation of 17-hydroxyprogesterone. This metabolic pathway is minor in normal subjects, in whom basal plasma concentrations range from 0.03 to 0.63 nmol/L and from 0.865 to 1.50 nmol/L
M Hill et al.
Steroids, 60(9), 615-620 (1995-09-01)
A radioimmunoassay of three deoxycorticoids, namely 11 beta,17 alpha-dihydroxy-4-pregnene-3,20-dione (21-deoxycortisol), 17 alpha,21-dihydroxy-4-pregnene-3,20-dione (11-deoxycortisol), and 21-hydroxy-4-pregnene-3,20-dione (11-deoxycorticosterone) which are important for differential diagnosis of congenital adrenal disorders, is described and evaluated. Antisera against 3-(O-carboxymethyl)oximes conjugated to bovine serum albumin were raised
Diagnosing Cushing's syndrome.
A A Ismail et al.
Annals of clinical biochemistry, 35 ( Pt 2), 324-325 (1998-04-21)
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