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表单
powder
包装
pkg of 1 × 5 mg (860479P-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 860479P
脂质类型
sphingolipids
bioactive lipids
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@](NC(CC12C[C@H]3C[C@@H](C2)C[C@@H](C1)C3)=O)([H])CO[C@H](O4)[C@H](O)[C@@H](O)[C@@H](O)[C@H]4CO
InChI key
JJKSFVGDPSOVJH-WQVUVXLKSA-N
生化/生理作用
Adamantyl galactosylceramide (adaGalCer), a glycosphingolipid (GSL) analog, modulates abnormal GSL turnover. It functions as an inhibitor and an alternative substrate to regulate cellular GSL metabolism in a particular manner. AdaGalCer blocks cell sulfatide synthesis and microsomal globotriaosyl ceramide (Gb3) synthesis. It reduces glucosylceramide (GlcCer) levels in normal and lysosomal storage disease (LSD) cells.
包装
5 mL Amber Glass Screw Cap Vial (860479P-5mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Adamantyl glycosphingolipids provide a new approach to the selective regulation of cellular glycosphingolipid metabolism
Kamani M, et al.
The Journal of Biological Chemistry, 286(24), 21413-21426 (2011)
Mustafa Kamani et al.
The Journal of biological chemistry, 286(24), 21413-21426 (2011-04-27)
Mammalian glycosphingolipid (GSL) precursor monohexosylceramides are either glucosyl- or galactosylceramide (GlcCer or GalCer). Most GSLs derive from GlcCer. Substitution of the GSL fatty acid with adamantane generates amphipathic mimics of increased water solubility, retaining receptor function. We have synthesized adamantyl
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