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化驗
>99% (TLC)
形狀
powder
分子量
997.17 g/mol
包裝
pkg of 1 × 25 mg (850538P-25mg)
製造商/商標名
Avanti Research™ - A Croda Brand 850538P
技術
protein quantification: suitable
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
[H][C@@]12[C@]([C@](CC[C@@H](OCCO[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C4)(C)[C@]4([H])C[C@H]2OCCO[C@@H]5[C@@H](O)[C@H](O)[C@@H](O)[C@H](CO)O5)([H])C[C@H](OCCO[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@]7(C)[C@@]1([H])CC[C@@H]7[C@H](C)CCC
一般說明
Facade™ TEG/FA-5 (3α,7α,12α-tri-((O-β-D-glucopyranosyl)ethyloxy)-cholane) carries three sugar (maltoside/glucoside) attachments on the steroid backbone.
生化/生理作用
Facade™ TEG/FA-5 (3α,7α,12α-tri-((O-β-D-glucopyranosyl)ethyloxy)-cholane), a sugar-based facial amphiphile can be used in membrane protein (MP) crystallization experiments. Facade-TEG helps to enhance the thermostability of type II cannabinoid receptor (CB2). Facade detergents acts as the best platform for biophysical characterization of G protein-coupled receptor (GPCR).
包裝
5 mL Amber Glass Screw Cap Vial (850538P-25mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Facade is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
The Journal of biological chemistry, 295(1), 181-190 (2019-11-30)
G protein-coupled receptors (GPCRs) comprise a large class of integral membrane proteins involved in the regulation of a broad spectrum of physiological processes and are a major target for pharmaceutical drug development. Structural studies can help advance the rational design
Designing facial amphiphiles for the stabilization of integral membrane proteins.
Angewandte Chemie (International ed. in English), 46(37), 7023-7025 (2007-08-11)
Proceedings of the National Academy of Sciences of the United States of America, 110(13), E1203-E1211 (2013-03-13)
Amphiphile selection is a critical step for structural studies of membrane proteins (MPs). We have developed a family of steroid-based facial amphiphiles (FAs) that are structurally distinct from conventional detergents and previously developed FAs. The unique FAs stabilize MPs and
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