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Merck

850538P

Avanti

Facade-TEG

3α,7α,12α-tri-((O-β-D-glucopyranosyl)ethyloxy)-cholane, powder

别名:

FA-5

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About This Item

经验公式(希尔记法):
C48H84O21
分子量:
997.17
分類程式碼代碼:
12161902
NACRES:
NA.25

化驗

>99% (TLC)

形狀

powder

分子量

997.17 g/mol

包裝

pkg of 1 × 25 mg (850538P-25mg)

製造商/商標名

Avanti Research - A Croda Brand 850538P

技術

protein quantification: suitable

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[H][C@@]12[C@]([C@](CC[C@@H](OCCO[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C4)(C)[C@]4([H])C[C@H]2OCCO[C@@H]5[C@@H](O)[C@H](O)[C@@H](O)[C@H](CO)O5)([H])C[C@H](OCCO[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@]7(C)[C@@]1([H])CC[C@@H]7[C@H](C)CCC

一般說明

Facade TEG/FA-5 (3α,7α,12α-tri-((O-β-D-glucopyranosyl)ethyloxy)-cholane) carries three sugar (maltoside/glucoside) attachments on the steroid backbone.

生化/生理作用

Facade TEG/FA-5 (3α,7α,12α-tri-((O-β-D-glucopyranosyl)ethyloxy)-cholane), a sugar-based facial amphiphile can be used in membrane protein (MP) crystallization experiments. Facade-TEG helps to enhance the thermostability of type II cannabinoid receptor (CB2). Facade detergents acts as the best platform for biophysical characterization of G protein-coupled receptor (GPCR).

包裝

5 mL Amber Glass Screw Cap Vial (850538P-25mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC
Facade is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids


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Ryan L Beckner et al.
The Journal of biological chemistry, 295(1), 181-190 (2019-11-30)
G protein-coupled receptors (GPCRs) comprise a large class of integral membrane proteins involved in the regulation of a broad spectrum of physiological processes and are a major target for pharmaceutical drug development. Structural studies can help advance the rational design
Designing facial amphiphiles for the stabilization of integral membrane proteins.
Qinghai Zhang et al.
Angewandte Chemie (International ed. in English), 46(37), 7023-7025 (2007-08-11)
Sung Chang Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(13), E1203-E1211 (2013-03-13)
Amphiphile selection is a critical step for structural studies of membrane proteins (MPs). We have developed a family of steroid-based facial amphiphiles (FAs) that are structurally distinct from conventional detergents and previously developed FAs. The unique FAs stabilize MPs and

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