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Merck
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文件

850153P

Avanti

PI (3,4) P2：18:1

1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′-bisphosphate) (ammonium salt), powder

别名:

1,2-二-（9Z十八烯酰基）-sn-甘油-3-[磷酸肌醇-3,4-二磷酸]（铵盐)；PIP2[3′,4′](18:1(9Z)/18:1(9Z))

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About This Item

经验公式（希尔记法）:
C45H94N3O19P3
CAS号:
799268-54-5
分子量:
1074.16
分類程式碼代碼:
51191904
NACRES:
NA.25

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 100 μg (with stopper and crimp cap (850153P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850153P-500ug))

製造商／商標名

Avanti Research™ - A Croda Brand 850153P

脂質類型

phospholipids
cardiolipins

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[H][C@@](COP(O[C@H]1[C@H](O)[C@@H](O)[C@H](OP(O)([O-])=O)[C@@H](OP(O)([O-])=O)[C@H]1O)([O-])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+].[NH4+].[NH4+]

相关类别

一般說明

18:1 PI（3,4）P2（1，2-二油酰基-sn-甘油-3-磷酸-（1′-肌醇-3′,4′-二磷酸））是修饰脂质的铵盐。
肌醇磷脂物质是膜结合的信号分子，它参与细胞生理学的几乎所有方面，包括细胞生长、代谢、增殖和存活。

應用

18:1 PI（3,4）P2（1，2-二油酰基-sn-甘油-3-磷酸-（1′-肌醇-3′,4′-二磷酸）（铵盐））已用于：
  • 脂质体/支持的脂质双分子层制备
  • 脂质体共沉淀
  • 阴离子磷脂脂质体的制备

生化／生理作用

PI（3，4）P2可以充当脂质第二信使。在肥大细胞中，PI（3，4）P2在Ser473位点的蛋白激酶B（PKB）磷酸化中起关键作用。

包裝

带塞子和压接盖的2 mL棕色血清瓶（850153P-100ug）
带塞子和压接盖的2 mL棕色血清瓶（850153P-500ug）

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

分析证书(COA)

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Arthur P H de Jong et al.
Neuron, 98(2), 335-349 (2018-04-03)
Rapid and efficient synaptic vesicle fusion requires a pool of primed vesicles, the nearby tethering of Ca2+ channels, and the presence of the phospholipid PIP2 in the target membrane. Although the presynaptic active zone mediates the first two requirements, it
Kewei Ma et al.
Cellular signalling, 20(4), 684-694 (2008-02-06)
The PI3K-PKB pathway is an important and widely studied pathway in cell signaling. The enzyme activity of PI3K produces D-3 phosphoinositides, including the lipid second messengers PI(3,4,5)P3 and PI(3,4)P2. PI(3,4,5)P3 has been deemed to be the most important second messenger
Yelena Ugolev et al.
The Journal of biological chemistry, 283(32), 22257-22271 (2008-05-29)
Rac plays a pivotal role in the assembly of the superoxide-generating NADPH oxidase of phagocytes. In resting cells, Rac is found in the cytosol in complex with Rho GDP dissociation inhibitor (RhoGDI). NADPH oxidase assembly involves dissociation of the Rac.RhoGDI
Iris K Jarsch et al.
The Journal of cell biology, 219(4) (2020-04-25)
Filopodia are finger-like actin-rich protrusions that extend from the cell surface and are important for cell-cell communication and pathogen internalization. The small size and transient nature of filopodia combined with shared usage of actin regulators within cells confounds attempts to
Gerald R V Hammond et al.
Science (New York, N.Y.), 337(6095), 727-730 (2012-06-23)
The quantitatively minor phospholipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P(2)] fulfills many cellular functions in the plasma membrane (PM), whereas its synthetic precursor, phosphatidylinositol 4-phosphate (PI4P), has no assigned PM roles apart from PI(4,5)P(2) synthesis. We used a combination of pharmacological and chemical

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