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Merck
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文件

840030C

Avanti

06:0 PS

1,2-dihexanoyl-sn-glycero-3-phospho-L-serine (sodium salt), chloroform

别名:

PS(6:0/6:0)

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About This Item

经验公式（希尔记法）:
C18H33NO10PNa
CAS号:
321862-85-5
分子量:
477.42
分類程式碼代碼:
51191904
NACRES:
NA.25

化驗

>99% (TLC)

形狀

liquid

包裝

pkg of 1 × 1 mL (840030C-10mg)
pkg of 1 × 2.5 mL (840030C-25mg)

製造商／商標名

Avanti Research™ - A Croda Brand 840030C

濃度

10 mg/mL (840030C-10mg)
10 mg/mL (840030C-25mg)

脂質類型

phospholipids
cardiolipins

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCC)=O)COC(CCCCC)=O.[Na+]

InChI

1S/C18H34NO10P.Na/c1-3-5-7-9-16(20)26-11-14(29-17(21)10-8-6-4-2)12-27-30(24,25)28-13-15(19)18(22)23;/h14-15H,3-13,19H2,1-2H3,(H,22,23)(H,24,25);/q;+1/p-1/t14-,15+;/m1./s1

InChI 密鑰

OPDYVXCKOQKYDZ-LIOBNPLQSA-M

相关类别

一般說明

Phosphoserine/phosphatidylserine (PS) is an endogenous phospholipid, that is found in all polyanionic macromolecules like bone, enamel and dentin.

應用

06:0 PS may be used:
  • to study its effect on α-syn (α-synuclein) oligomerization by DA (dopamine)
  • to prepare phosphatidylserine (PS) liposomes
  • as a phospholipid substrate to determine the kinetic parameters for phospholipase C by chromogenic assay

生化／生理作用

Phosphoserine (PS) can be used as a template moiety for the recognition of cancer antigen 125 (CA 125). It is essential for healthy nerve cell membranes and myelin. Exogenous PS can be actively absorbed in humans and is blood-brain barrier traversable. PS actively participates in the locomotor functions.

包裝

5 mL Clear Glass Sealed Ampule (840030C-10mg)
5 mL Clear Glass Sealed Ampule (840030C-25mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險分類

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

標靶器官

Central nervous system

水污染物質分類（WGK）

WGK 3

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Athena Sudom et al.
The Journal of biological chemistry, 293(32), 12634-12646 (2018-05-26)
Triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor expressed on the surface of microglia, macrophages, dendritic cells, and osteoclasts. The R47H TREM2 variant is a significant risk factor for late-onset Alzheimer's disease (AD), and the molecular
Lhaj Benaziz et al.
Journal of colloid and interface science, 238(1), 48-53 (2001-05-15)
The adsorption of phosphoserine and serine was studied to determine the effect of amino acid functional groups on the surface reactivity of synthetic poorly crystalline apatite similar to bone mineral. The experimental results for phosphoserine and serine uptake agree respectively
Chi L L Pham et al.
Bioscience reports, 33(5) (2013-09-27)
The deposition of α-syn (α-synuclein) as amyloid fibrils and the selective loss of DA (dopamine) containing neurons in the substantia nigra are two key features of PD (Parkinson's disease). α-syn is a natively unfolded protein and adopts an α-helical conformation
Sibel Büyüktiryaki et al.
Talanta, 167, 172-180 (2017-03-28)
Cancer antigen 125 (CA 125) is widely used as diagnostic biomarker for ovarian cancer. Change in the concentration level of CA 125 is associated with disease progression or regression. CA 125 posseses a phosphorylation site and protein backbone is phosphorylated
P J Hergenrother et al.
Analytical biochemistry, 251(1), 45-49 (1997-08-15)
The kinetic parameters of the phosphatidylcholine-preferring phospholipase C from Bacillus cereus (PLCBc) have been evaluated for phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine substrates with a new assay based on the quantitation of inorganic phosphate (Pi). Treatment of the phosphomonoester product of the
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商品

Critical Micelle Concentrations (CMCs) - Avanti® Polar Lipids

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn

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