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Merck
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文件

A76001

Sigma-Aldrich

(±)-3-氨基-1,2-丙二醇

97%

别名:

(±)-3-氨基-1,2-羟丙烷, 1-氨基甘油, 2,3-二羟丙烷-1-胺, 3-氨基-2-羟丙醇

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About This Item

线性分子式:
NH2CH2CH(OH)CH2OH
CAS号:
616-30-8
分子量:
91.11
Beilstein:
1719121
EC號碼:
210-475-8
MDL號碼:
MFCD00008140
分類程式碼代碼:
12352100
PubChem物質ID:
24891256
NACRES:
NA.22

化驗

97%

形狀

liquid

折射率

n20/D 1.492 (lit.)

bp

264-265 °C/739 mmHg (lit.)

密度

1.175 g/mL at 25 °C (lit.)

SMILES 字串

NCC(O)CO

InChI

1S/C3H9NO2/c4-1-3(6)2-5/h3,5-6H,1-2,4H2

InChI 密鑰

KQIGMPWTAHJUMN-UHFFFAOYSA-N

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應用

(±)-3-氨基-1,2-丙二醇是被用作合成用于RNA干扰（RNAi）治疗的脂质样递送分子（类脂质）的一种反应物。它还用于合成生物活性模板以制备阳离子α-螺旋多肽和各种阳离子聚合物用于基因递送。

象形圖

Corrosion
GHS05

訊號詞

Danger

危險聲明

H314

危險分類

Skin Corr. 1B

儲存類別代碼

8A - Combustible corrosive hazardous materials

水污染物質分類（WGK）

WGK 2

閃點（°F）

235.4 °F - closed cup

閃點（°C）

113 °C - closed cup

個人防護裝備

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery.
Anderson DG, et al.
Angewandte Chemie (International Edition in English), 115(27), 3261-3266 (2003)
Reactive and bioactive cationic ?-helical polypeptide template for nonviral gene delivery.
Gabrielson NP, et al.
Angewandte Chemie (International Edition in English), 51(5), 1143-1147 (2012)
J W Morzycki et al.
Acta poloniae pharmaceutica, 58(4), 249-256 (2001-11-06)
Three new derivatives of 3-amino-1,2-propanediol have been synthesized. Full assignments of signals in their 1H- and 13C-NMR spectra are given. The influence of these compounds on the cardiovascular system in the anaesthetized rat was examined. In contrast to CGP 12177
B W Day et al.
Chemical research in toxicology, 4(3), 359-363 (1991-05-01)
Human hemoglobin was alkylated with (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) and then treated with aqueous (+/-)-3-amino-1,2-propanediol to convert alkylated carboxyl side chains to N-(2,3-dihydroxypropyl) amides. Tryptic peptides produced from the modified protein were subjected to affinity chromatography on phenylboronic
R Dijkman et al.
Biochimica et biophysica acta, 1043(1), 67-74 (1990-03-12)
This paper describes the synthesis of a number of phosphatidylcholines and phosphatidylglycols, in which one fatty acyl ester group is replaced by an acylamino function. The phospholipids, both of the alpha- and beta-type, are prepared in racemic and enantiomeric pure
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