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化驗
>99% (TLC)
形狀
liquid
包裝
pkg of 1 × 1 mL (810218C-1mg)
製造商／商標名
Avanti Research™ - A Croda Brand 810218C
濃度
1 mg/mL (810218C-1mg)
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
[P](=O)([O-])(OC[C@H](NC(=O)CCCCCNc1c2n[o]nc2c(cc1)[N+](=O)[O-])[C@H](O)\C=C\CCCCCCCCCCCCC)OCC[N+](C)(C)C
InChI
1S/C35H61N6O9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-18-21-32(42)30(28-49-51(46,47)48-27-26-41(2,3)4)37-33(43)22-19-17-20-25-36-29-23-24-31(40(44)45)35-34(29)38-50-39-35/h18,21,23-24,30,32,42H,5-17,19-20,22,25-28H2,1-4H3,(H2-,36,37,39,43,46,47)/b21-18+/t30-,32+/m0/s1
InChI 密鑰
YDBDYTGWMRUUSN-PERJAUJZSA-N
一般說明
C6-NBD Sphingomyelin is a fluorescent derivative of sphingomyelin. Its fluorescent property is due to presence of NBD (2-(4-nitro-2,1,3-benzoxadiazol-7-yl) aminoethyl) group. Sphingomyelin is generally concentrated in the outer leaflet of the plasma membrane.
應用
C6-NBD Sphingomyelin is suitable to study sphingomyelin endocytosis using fluorescence microscopy.
生化／生理作用
Sphingomyelin (SM) is involved in signal transduction and membrane trafficking. It is synthesized by the transfer of phosphocholine from phosphatidylcholine onto ceramide, catalysed by sphingomyelin synthase on the cell surface and in lumen of the Golgi. SM has high packing density and affinity for sterol which offer a strong barrier to extracellular environment.
包裝
5 mL Amber Glass Screw Cap Vial (810218C-1mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
訊號詞
Danger
危險分類
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
標靶器官
Central nervous system, Liver,Kidney
水污染物質分類（WGK）
WGK 3
Fluorescent and Luminescent Probes for Biological Activity (1999)
Kristin Dauner et al.
The Journal of biological chemistry, 292(14), 5737-5747 (2017-02-16)
The plasma membrane of mammalian cells undergoes constitutive endocytosis, endocytic sorting, and recycling, which delivers nutrients to the lysosomes. The receptors, along with membrane lipids, are normally returned to the plasma membrane to sustain this action. It is not known
mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery
Dauner K, et al.
The Journal of biological chemistry, 292(14), 5737-5747 (2017)
Klazien Huitema et al.
The EMBO journal, 23(1), 33-44 (2003-12-20)
Sphingomyelin (SM) is a major component of animal plasma membranes. Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, yielding diacylglycerol as a side product. This reaction is catalysed by SM synthase, an enzyme whose biological potential can
Mark L Schultz et al.
BMC medicine, 17(1), 200-200 (2019-11-13)
Niemann-Pick disease type C is a fatal and progressive neurodegenerative disorder characterized by the accumulation of unesterified cholesterol in late endosomes and lysosomes. We sought to develop new therapeutics for this disorder by harnessing the body's endogenous cholesterol scavenging particle
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