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Merck

700048P

Avanti

24(R/S),25-epoxycholesterol-d6

Avanti Research - A Croda Brand

别名:

26,26,26,27,27,27-hexadeutero-24,25-epoxycholesterol

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About This Item

经验公式(希尔记法):
C27H38O2D6
分子量:
406.67
MDL號碼:
分類程式碼代碼:
41116107
NACRES:
NA.25

描述

24(R/S),25-epoxycholesterol-d6

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 1 mg (700048P-1mg)

製造商/商標名

Avanti Research - A Croda Brand

運輸包裝

dry ice

儲存溫度

−20°C

一般說明

24(R/S),25-epoxycholesterol-d6 is a deuterated side-chain substituted oxysterol.

應用

24(R/S),25-epoxycholesterol-d6 has been used as a primary and deuterated surrogate sterol standard in the quantitative analysis of extracted sterol samples from cultured cells and tissues.

生化/生理作用

24(S),25-epoxycholesterol maintains cholesterol homeostasis. It modulates hepatic cholesterol metabolism in vivo. 24(S),25-epoxycholesterol is synthesized in the mevalonate pathway. It inhibits sterol regulatory element-binding protein (SREBP) activation.
Deuterated sterol plays a vital role in chemical and biochemical research. It is used as a mechanistic tracer to study the role of steroid hormones in the function and modulation of several physiological processes. Deuterated sterol is also used as reference standards for mass spectrometry. 24(R/S),25-epoxycholesterol-d6 is a deuterium labeled sterol.

包裝

5 mL Amber Glass Screw Cap Vial (700048P-1mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Site-specific synthesis and application of Deuterium-Labeled sterols
Muchalski H, et al.
Archive for Organic Chemistry (2017)
24 (S), 25-epoxycholesterol: a messenger for cholesterol homeostasis
Brown AJ
The International Journal of Biochemistry & Cell Biology, 41(4), 744-747 (2019)
Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry
McDonald J, et al.
Test, 432, 145-170 (2007)
Jeffrey G McDonald et al.
Methods in enzymology, 432, 145-170 (2007-10-24)
We describe the development of a high performance liquid chromatography mass spectrometry (HPLC-MS) method that allows the identification and quantitation of sterols in mammalian cells and tissues. Bulk lipids are extracted from biological samples by a modified Bligh/Dyer procedure in

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