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Merck

C22415

Sigma-Aldrich

4-氯苯胺

98%

别名:

1-Amino-4-chlorobenzene, 4-Chlorophenylamine, p-Chloroaniline

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About This Item

线性分子式:
ClC6H4NH2
CAS号:
分子量:
127.57
Beilstein:
471359
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

蒸汽密度

4.4 (vs air)

品質等級

蒸汽壓力

0.15 mmHg ( 25 °C)

化驗

98%

形狀

chips
crystals or chunks

bp

232 °C (lit.)

mp

67-70 °C (lit.)

SMILES 字串

Nc1ccc(Cl)cc1

InChI

1S/C6H6ClN/c7-5-1-3-6(8)4-2-5/h1-4H,8H2

InChI 密鑰

QSNSCYSYFYORTR-UHFFFAOYSA-N

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應用

4-氯苯胺可用于:
  • 超声作用下通过烯丙基化形成N-烯丙基-4-氯苯胺,一种含吲哚和二氢吲哚核的生物活性化合物的前体。
  • 与环戊二烯进行Povarov反应生成C-2脂肪族取代四氢喹啉。
  • 与醛和环酮进行曼尼希反应生成β-氨基羰基化合物。
  • 在硝酸胍的存在下硝化形成4-氯-3-硝基苯胺。

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Skin Sens. 1

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

248.0 °F - closed cup

閃點(°C)

120.0 °C - closed cup

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Factorial study to assess an ultrasonic methodology for the allylation of 4-chloroaniline
Nascimento LFS and Fernandes JPS
Green Processing and Synthesis, 6(2), 203-209 (2017)
Guanidinium nitrate: a novel reagent for aryl nitrations
Ramana MMV, et al.
Tetrahedron Letters, 45(47), 8681-8683 (2004)
Highly efficient one-pot, three-component Mannich reaction catalysed by boric acid and glycerol in water with major `syn?diastereoselectivity
Mukhopadhyay C, et al.
Tetrahedron Letters, 50(29), 4246-4250 (2009)
Lanthanide (III)-catalyzed multi-component aza-Diels-Alder reaction of aliphatic N-arylaldimines with cyclopentadiene.
Powell DA and Batey RA.
Tetrahedron Letters, 44(41), 7569-7573 (2003)
D Mortenson et al.
International endodontic journal, 45(9), 878-882 (2012-04-11)
To determine if the formation of para-chloroaniline (PCA) can be avoided by using an alternative irrigant following sodium hypochlorite but before chlorhexidine. Fifty-five single-rooted teeth were decoronated, instrumented to size 40, .06 taper whilst being irrigated with 14% ethylene-diamine-tetra-acetic acid

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