935166

Hyaluronic acid

acid form, average M_w 25,000

• 别名: HA
• 线性分子式: (C₁₆H₂₇NO₁₁)_n
• CAS号: 9004-61-9
• MDL號碼: MFCD00131348
• 分類程式碼代碼: 51202002
• NACRES: NA.21

属性

• 描述: acid form of hylauronic acid
• 品質等級: 100
• 形狀: powder or chunks (or Fibers)
• 分子量: average M_w 25,000
• 顏色: white to faint yellow, Faint Brown
• 應用: advanced drug delivery; (Tissue engineering)
• 儲存溫度: 2-8°C
• SMILES 字串: N(C1C(OC(C(C1OC4OC(C(C(C4O)O)O)C(=O)O)O)CO)OC2C(OC(C(C2O)O)OC3C(C(OC(C3O)CO)O)NC(=O)C)C(=O)O)C(=O)C
• InChI: 1S/C28H44N2O23/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45)
• InChI 密鑰: KIUKXJAPPMFGSW-UHFFFAOYSA-N

说明

一般說明

Hyaluronic acid (HA) is a a natural polymer found in many extracellular matrices (ECM). Its biocompatibility, biodegradability, and biomimetic chacteristics make it one of the most advantagous biopolymers for myriad of biomedical applications including drug delivery, tissue engineering, hydrogel development, cosmetics, regenerative medicine and 3D bioprinting.
Unlike other HA products which are typically available in a sodium salt form, HA acid form is soluble in organic solvents such as DMSO. This allows for a larger range of possible chemical modifications and functionalization. For instance, the carboxylic acid of the glucoronic acid can be modified or functionalized with hydrazine end groups.

應用

• Tissue engineering including cartilage tissue engineering, bone tissue engineering, and other musculoskeletal tissues
• Drug delivery and a carrier of small molecules, large molecules, and biomolecules
• Biosensors, films and transdermal microneedles development
• Medical device coatings, wound healing, and cosmetics

特點和優勢

• The same advantages of HA but in acid form
• Soluble in organic solvents such as DMSO
• Larger range of chemical modifications and functionalization possibilities

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable