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Merck

904848

Sigma-Aldrich

2-Chloro-1,3-bis(2,6-diisopropylphenyl)imidazolium chloride

≥95%

别名:

1,3-Bis(2,6-di-i-propylphenyl)-2-chloroimidazolium chloride, Chloroimidazolium chloride

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About This Item

经验公式(希尔记法):
C27H36Cl2N2
分子量:
459.49
MDL號碼:
分類程式碼代碼:
12352101
NACRES:
NA.22

化驗

≥95%

形狀

powder

InChI

1S/C27H36ClN2.ClH/c1-17(2)21-11-9-12-22(18(3)4)25(21)29-15-16-30(27(29)28)26-23(19(5)6)13-10-14-24(26)20(7)8;/h9-20H,1-8H3;1H/q+1;/p-1

InChI 密鑰

JDMACANGISWEGX-UHFFFAOYSA-M

應用

This chloroimidazolium chloride is used in the deoxyfluorination of phenols. Recently, the Ritter lab used it in conjunction with 902314 and 906794 to incorporate the [18F]fluoride radiolabel site specifically into polypeptides for use with positron emission tomography (PET) imaging in the study of various biological applications.

Automate your fluorination reactions with Synple Automated Synthesis Platform (SYNPLE-SC002)

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Teppei Fujimoto et al.
Organic letters, 17(3), 544-547 (2015-01-27)
A practical deoxyfluorination with novel deoxyfluorinating reagent PhenoFluorMix, a mixture of N,N'-1,3-bis(2,6-diisopropylphenyl)chloroimidazolium chloride and CsF, is presented. PhenoFluorMix overcomes the challenges associated with hydrolysis of PhenoFluor. PhenoFluorMix does not hydrolyze, is readily available on decagram scale, and is storable in
Corrigendum: Concerted nucleophilic aromatic substitution with 19F- and 18F.
Constanze N Neumann et al.
Nature, 538(7624), 274-274 (2016-08-04)
Nathaniel W Goldberg et al.
Organic letters, 18(23), 6102-6104 (2016-12-10)
A practical, high-yielding method for the deoxyfluorination of alcohols is presented using AlkylFluor, a novel salt analogue of PhenoFluor. AlkylFluor is readily prepared on multigram scale and is stable to long-term storage in air and exposure to water. The practicality
Jisu Back et al.
Journal of the American Chemical Society, 139(43), 15300-15303 (2017-10-19)
Notwithstanding the notable progress in the synthesis of N-heterocyclic carbene-stabilized radicals, aminyl radicals, supported by NHCs or otherwise, have been scarcely studied due to synthetic challenges. Triazenyl radical is a particular form of aminyl radical that contains three adjacent nitrogen
Martin G Strebl et al.
ACS central science, 3(9), 1006-1014 (2017-10-06)
Histone deacetylase 6 (HDAC6) function and dysregulation have been implicated in the etiology of certain cancers and more recently in central nervous system (CNS) disorders including Rett syndrome, Alzheimer's and Parkinson's diseases, and major depressive disorder. HDAC6-selective inhibitors have therapeutic

相关内容

The Ritter lab currently focuses on fluorination chemistry for late-stage functionalization of complex natural and unnatural products. PhenoFluor™ has been developed as a general reagent for the selective, predictable, direct deoxyfluorination of complex alcohols and phenols.

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