803669

SIAB (N-succinimidyl (4-iodoacetyl)aminobenzoate)

• 经验公式（希尔记法）: C₁₃H₁₁N₂O₅I
• CAS号: 72252-96-1
• 分子量: 402.14
• MDL號碼: MFCD00054976
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329768825
• NACRES: NA.22

属性

• 化驗: ≥95%
• 形狀: powder
• 分子量: 402.15
• 反應適用性: reagent type: cross-linking reagent
• 儲存條件: desiccated
• 溶解度: DMSO or DMF: soluble
• 官能基: NHS ester
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(CCC1=O)N1OC(C2=CC=C(NC(CI)=O)C=C2)=O
• InChI: 1S/C13H11IN2O5/c14-7-10(17)15-9-3-1-8(2-4-9)13(20)21-16-11(18)5-6-12(16)19/h1-4H,5-7H2,(H,15,17)
• InChI 密鑰: BQWBEDSJTMWJAE-UHFFFAOYSA-N

说明

一般說明

SIAB is an amine- and sulfhydryl-reactive heterobifunctional crosslinker and Sulfo-SIAB is its water-soluble analog. These crosslinkers contain an amine-reactive N-hydroxysuccimide (NHS) ester and a sulfhydryl-reactive iodoacetyl group, and are often used for preparing enzyme conjugates or immunotoxins. Water-soluble and water-insoluble forms of NHS esters have essentially identical reactivity. Sulfo-SIAB is supplied as a sodium salt and is water-soluble to ~10mM. SIAB must be first dissolved in an organic solvent, such as DMSO or DMF, and then added to the aqueous reaction mixture. SIAB is lipophilic, membrane-permeable and does not possess a charged group.

特點和優勢

• Reactive groups: NHS ester and iodoacetyl
• Reactive toward: amino and sulfhydryl groups
• Non-cleavable
• Water-insoluble (dissolve first in DMF or DMSO); compare to Sulfo-SIAB
• Used to prepare stable enzyme-IgG conjugates
• Forms conjugates with liposomes

注意

This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable