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等級
produced by Wacker Chemie AG, Burghausen, Germany
化驗
≥95.0% cyclodextrin basis (calculated)
形狀
powder
標籤範圍
1.6-1.9 molar substitution
雜質
≤0.2% unsubstituted cyclodextrin
≤0.2% volatile organics
≤2% chloride
損耗
≤7.0% loss on drying
mp
180-182 °C (lit.)
InChI
1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3
InChI 密鑰
QGKBSGBYSPTPKJ-UHFFFAOYSA-N
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應用
在单乙醇胺(MEA)存在下，甲基-β-环糊精（M-β-CD）可作为反应物制备双氯芬酸(DCF)三元包合物。该复合物改善了DCF在人体皮肤中的经皮吸收。它也可用于与奥氮平(OLP)形成包合物，用于提高其溶解度，以实现有效的药物递送。
其他說明
仅供R&D使用
法律資訊
Cavasol is a registered trademark of Wacker Chemie AG
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
368.6 °F
閃點（°C）
187 °C
其他客户在看
María Julia Mora et al.
European journal of medicinal chemistry, 45(9), 4079-4088 (2010-06-23)
Here, we describe the chemical characterization of the inclusion complex between diclofenac (DCF) and methyl-beta-cyclodextrin (M-beta-CD) in the presence or absence of monoethanolamine (MEA). Several techniques were used to analyze the complex both in solution and in the solid state.
Inclusion complex of methyl-β -cyclodextrin and olanzapine as potential drug delivery system for schizophrenia
de Freitas MR, et al.
Carbohydrate Polymers, 89(4), 1095-1100 (2012)
Sara Rodríguez-Acebes et al.
The Biochemical journal, 420(2), 305-315 (2009-03-06)
Cholesterol homoeostasis is critical for cell viability and proliferation. The SREBP (sterol regulatory element-binding protein) pathway is crucial for the maintenance of cholesterol homoeostasis. This pathway is controlled by cholesterol and cholesterol-derived oxysterols. J774 cells cannot convert desmosterol into cholesterol
Maoyong Fu et al.
PloS one, 6(5), e19945-e19945 (2011-06-04)
Endometrial cancer is the most common gynecologic malignancy diagnosed among women in developed countries. One recent biomarker strongly associated with disease progression and survival is epithelial membrane protein-2 (EMP2), a tetraspan protein known to associate with and modify surface expression
William E Brownell et al.
Pflugers Archiv : European journal of physiology, 461(6), 677-686 (2011-03-05)
Changing the concentration of cholesterol in the plasma membrane of isolated outer hair cells modulates electromotility and prestin-associated charge movement, suggesting that a similar manipulation would alter cochlear mechanics. We examined cochlear function before and after depletion of membrane cholesterol
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