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765090

Sigma-Aldrich

聚乙烯亚胺，线性

average Mn 10,000, PDI ≤1.3

别名:

PEI

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About This Item

线性分子式:
(CH2CH2NH)n
CAS号:
9002-98-6
MDL编号:
MFCD00039669
UNSPSC代码:
12162002
NACRES:
NA.23

表单

solid

质量水平

100

分子量

average Mn 10,000

mp

48-53 °C

PDI

≤1.3

储存温度

2-8°C

SMILES字符串

N1CC1

InChI

1S/C2H5N/c1-2-3-1/h3H,1-2H2

InChI key

NOWKCMXCCJGMRR-UHFFFAOYSA-N

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相关类别

一般描述

聚乙烯亚胺（线性）是一种用途广泛的阳离子聚合物，具有较高的转染效率。它可用作基因传递试剂。这是一种非脂质聚阳离子，可用于将寡核苷酸和质粒转染至体内和体外细胞。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319

危险分类

Eye Irrit. 2 - Skin Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCT7403
MKCT7400
MKCT7402
MKCT7401
MKCH4846

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A comparison of linear and branched polyethylenimine (PEI) with DCChol/DOPE liposomes for gene delivery to epithelial cells in vitro and in vivo
Wiseman JW, et al.
Gene Therapy, 10(19), 1654-1654 (2003)
Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse
Zou S, et al.
The journal of gene medicine, 2(2), 128-134 (2000)
Bromodomain and extra-terminal (BET) protein inhibitors suppress chondrocyte differentiation and restrain bone growth
Niu N, et al.
The Journal of biological chemistry, 291(52), 26647-26657 (2016)
Marie-Elise Bonnet et al.
Pharmaceutical research, 25(12), 2972-2982 (2008-08-19)
The success of nucleic acid therapies depends upon delivery vehicle's ability to selectively and efficiently deliver therapeutic nucleic acids to target organ with minimal toxicity. The cationic polymer polyethylenimine (PEI) has been widely used for nucleic acid delivery due to
Dae Hee Lee et al.
Biomaterials, 171, 34-45 (2018-04-22)
Limitation of current anti-Vascular Endothelial Growth Factor (VEGF) cancer therapy is transitory responses, inevitable relapses and its insufficient tumor-targeting. Thus, multifaceted approaches, including the development of bispecific antibodies and combination strategies targeting different pathways have been proposed as an alternative.
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