702757

叔戊氧基钾 溶液

2 M in THF

• 别名: 2-甲基-2-丁醇钾, 叔戊醇钾
• 线性分子式: CH₃CH₂C(CH₃)₂OK
• CAS号: 41233-93-6
• 分子量: 126.24
• Beilstein: 4149025
• MDL號碼: MFCD00064808
• 分類程式碼代碼: 12352001
• PubChem物質ID: 329762401
• NACRES: NA.22

属性

• 形狀: liquid
• 濃度: 2 M in THF
• 密度: 0.920 g/mL at 25 °C
• SMILES 字串: [K+].CCC(C)(C)[O-]
• InChI: 1S/C5H11O.K/c1-4-5(2,3)6;/h4H2,1-3H3;/q-1;+1
• InChI 密鑰: ZRLVQFQTCMUIRM-UHFFFAOYSA-N

说明

一般說明

Potassiumtert-pentoxide solution is a strong and sterically hindered alkoxide baseprepared by treating oil-free potassium hydride with anhydrous t-pentylalcohol in anhydrous solvent.

應用

Potassium tert-pentoxide solution can be used as a base in the:

• Wittig reaction of ketoesters with methyltriphenylphosphonium bromide to synthesize alkenes.
• Palladium-catalyzed Buchwald-Hartwig amination reaction.

It can also be used:

• To prepare potassium tert-pentoxide-crown ether complexes, which is used as a Lewis base catalyst in Mukaiyama aldol reaction.
• As an activator for (difluoromethyl)trimethylsilane to generate difluoromethyl-carbanion which reacts with isothiocyanate to synthesize α, α-difluoromethyl thioamide.

特點和優勢

In the absence of air and moisture, potassium tert-pentoxide solutions in benzene or toluene may be stored in a refrigerator for up to 1 year without significant deterioration.

安全信息

• 象形圖: GHS02,GHS08,GHS05,GHS07
• 訊號詞: Danger
• 危險聲明: H225,H302,H314,H335,H336,H351
• 防範說明: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
• 標靶器官: Central nervous system, Respiratory system
• 安全危害: EUH019
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: 1.4 °F - Solvent
• 閃點（°C）: -17 °C - Solvent
• 個人防護裝備: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter