所有图片(1)
About This Item
经验公式（希尔记法）:
C8H15NO2
CAS号:
分子量:
157.21
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
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方案
97%
表单
liquid
密度
1.092 g/mL at 25 °C
SMILES字符串
CCOC(=O)[C@@H]1CCCNC1
InChI
1S/C8H15NO2/c1-2-11-8(10)7-4-3-5-9-6-7/h7,9H,2-6H2,1H3/t7-/m1/s1
InChI key
XIWBSOUNZWSFKU-SSDOTTSWSA-N
应用
Reactant for synthesis of:
Reactant for stereocontrolled hydoiodination of alkynes
Used for an orally potent anti-anxiety drug
- DPP-4 inhibitors
- Dual H1/5-HT2A receptor antagonists for treatment of sleep disorders
- Serotonin and noradrenaline reuptake inhibitors
- GABA uptake inhibitors
Reactant for stereocontrolled hydoiodination of alkynes
Used for an orally potent anti-anxiety drug
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
219.2 °F
闪点(°C)
104 °C
个人防护装备
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
S H Zorn et al.
The Journal of pharmacology and experimental therapeutics, 242(1), 173-178 (1987-07-01)
Previous reports have suggested that the ethyl ester of (R)-nipecotic acid ethyl ester [(R)-NAEE] displays cholinomimetic properties in vivo. The present study was undertaken to characterize more fully this action by examining the effects of (R)-NAEE in a number of
T Andree et al.
Life sciences, 32(19), 2265-2272 (1983-05-09)
THIP (4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridone-3-ol), a direct acting GABA receptor agonist, has been shown to have antinociceptive properties. To determine whether tolerance develops to the analgesic response, mice received multiple injections of THIP for up to 21 days after which analgesia
M Potegal
Psychopharmacology, 89(4), 444-448 (1986-01-01)
The GABA uptake inhibitor ethyl (R,S)-nipecotate produces a dose-dependent suppression of aggression in highly aggressive hamsters but not in minimally aggressive ones. This suppression occurs at doses below those producing peripheral cholinergic effects; at the highest dose used it persists
Wen-Juan Zhao et al.
Acta pharmacologica Sinica, 24(10), 991-995 (2003-10-09)
The changes of seizure susceptibility of transgenic mice overexpressing GABA transporter-1 (GAT-1) were studied to clarify the possible role of GABAergic transmission in epileptogenesis. Seizures were induced by intraperitoneal administration of pentylenetetrazol (PTZ), picrotoxin (PIC), or kainic acid (KA) respectively.
A M Rustum et al.
Journal of pharmaceutical and biomedical analysis, 17(8), 1439-1447 (1998-11-04)
Chiral HPLC methods were developed and validated for tiagabine.HCl and its two chiral precursors to determine the chiral purity of the three compounds to ensure the quality of the final product which is used as a new antiepileptic drug. Tiagabine.HCl
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