CHRNA4
cholinergic receptor, nicotinic, alpha 4 (neuronal)
别名:
BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4
物种:
Human CHRNA4 (1137), Mouse Chrna4 (11438), Rat Chrna4 (25590), chicken CHRNA4 (395606), Domestic Rabbit CHRNA4 (100345481), sheep CHRNA4 (101118889), naked mole-rat Chrna4 (101714448), domestic guinea pig Chrna4 (100716877), cow CHRNA4 (537251), Zebrafish chrna4 (556619) ...展开
UniProtKB ID:
基因ID:
- Human(1137) Summary: This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
- Mouse(11438) cholinergic receptor, nicotinic, alpha polypeptide 4
- Rat(25590) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- chicken(395606) cholinergic receptor, nicotinic, alpha 4
- Domestic Rabbit(100345481) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- sheep(101118889) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- naked mole-rat(101714448) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- domestic guinea pig(100716877) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- cow(537251) cholinergic receptor, nicotinic, alpha 4
- Zebrafish(556619) cholinergic receptor, nicotinic, alpha 4
- Horse(100146784) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- domestic cat(101101300) cholinergic receptor, nicotinic, alpha 4 (neuronal)
- dog(485972) cholinergic receptor, nicotinic, alpha 4 (neuronal)
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Small Molecule - Agonist
货号
说明
物种
S(−)-尼古丁 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
物种
human
Small Molecule - Antagonist
Antibodies
货号
说明
物种反应性
应用
Anti-nAChR α4 Subunit Antibody, clone 369, clone 369, from mouse,
物种反应性
human, monkey, rabbit
应用
immunofluorescence
immunohistochemistry
immunohistochemistry
抗烟碱型乙酰胆碱受体α4抗体, from rabbit, purified by affinity chromatography,
物种反应性
human, mouse, rat
应用
western blot
Anti-ACHA4 antibody produced in rabbit, ,
物种反应性
human, mouse, rat
应用
immunohistochemistry
western blot
western blot
Anti-CHRNA4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot