SML0091

L-Dopa ethyl ester

≥98% (HPLC)

• Sinónimos: 3,4-Dihydroxy-L-phenylalanine ethyl ester, 3-Hydroxy-L-tyrosine ethyl ester, Etilevodopa, L-Dopa ethyl ester, L-Dopa-Et, Levodopa ethyl ester, O-Ethyl-DOPA, TV-1203
• Fórmula empírica (notación de Hill): C₁₁H₁₅NO₄
• Número de CAS: 37178-37-3
• Peso molecular: 225.24
• Número MDL: MFCD00871210
• Código UNSPSC: 12352108
• ID de la sustancia en PubChem: 329825151
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• actividad óptica: [α]/D +15 to +19°, c = 1 in methanol ([α]/D)
• color: white to tan
• solubilidad: H₂O: ≥12 mg/mL at warmed to 60 °C
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CCOC(=O)[C@@H](N)Cc1ccc(O)c(O)c1
• InChI: 1S/C11H15NO4/c1-2-16-11(15)8(12)5-7-3-4-9(13)10(14)6-7/h3-4,6,8,13-14H,2,5,12H2,1H3/t8-/m0/s1
• Clave InChI: NULMGOSOSZBEQL-QMMMGPOBSA-N
• Información sobre el gen: human ... DRD3(1814)

Descripción

Aplicación

L-Dopa ethyl ester has been used to study the protective effects of piperlongumine (PLG) on rotenone-induced Parkinson disease (PD).

Acciones bioquímicas o fisiológicas

L-Dopa ethyl ester (L-Dopa) is a dopamine replacement drug. It is used as a potent therapeutic for Parkinson disease (PD). L-Dopa has some long-term side effects, such as the deterioration of motor function.

L-Dopa ethyl ester is a prodrug of levodopa that has greater gastric solubility. The drug is rapidly hydrolyzed to levodopa by nonspecific esterases in the gastrointestinal tract. L-Dopa ethyl ester (etilevodopa)-carbidopa treatment was well tolerated but did not demonstrate better efficacy compared with standard levodopa-carbidopa treatment. L-Dopa ethyl ester should have a significant brain penetration following an administration by injection.

L-Dopa ethyl ester is prodrug of levodopa that has greater gastric solubility; antiparkinsonian agent

Características y beneficios

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302,H319
• Consejos de prudencia: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Clasificaciones de peligro: Acute Tox. 4 Oral - Eye Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable