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O9765

Sigma-Aldrich

Orientin

≥97% (HPLC)

Sinónimos:

8-β-D-Glucopyranosyl-3′,4′,5,7-tetrahydroxyflavone, Luteolin 8-C-β-D-glucopyranoside, Luteolin-8-glucoside, Lutexin

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About This Item

Fórmula empírica (notación de Hill):
C21H20O11
Número de CAS:
28608-75-5
Peso molecular:
448.38
Número MDL:
MFCD00017432
Código UNSPSC:
12352205
ID de la sustancia en PubChem:
329818945
NACRES:
NA.25

Nivel de calidad

100

Ensayo

≥97% (HPLC)

Formulario

powder

color

yellow

solubilidad

1 M NaOH: 1 mg/mL, clear, yellow-orange

aplicaciones

metabolomics
vitamins, nutraceuticals, and natural products

temp. de almacenamiento

2-8°C

cadena SMILES

OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c2c(O)cc(O)c3C(=O)C=C(Oc23)c4ccc(O)c(O)c4

InChI

1S/C21H20O11/c22-6-14-17(28)18(29)19(30)21(32-14)16-11(26)4-10(25)15-12(27)5-13(31-20(15)16)7-1-2-8(23)9(24)3-7/h1-5,14,17-19,21-26,28-30H,6H2/t14-,17-,18+,19-,21+/m1/s1

Clave InChI

PLAPMLGJVGLZOV-VPRICQMDSA-N

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Descripción general

Orientin (ORI) is a luteolin derivative and water soluble 8-C-glucoside dietary flavone. It has one ketone, two ether, and phenyl groups in its chemical structure. Orientin is sourced from many medicinal plants such as Ocimum sanctum (holy basil), Phyllostachys species (bamboo leaves), Passiflora species, Trollius species, etc.

Aplicación

Orientin has been used:
  • as an anti-inflammatory and anti-proliferative agent to test its protective effects against 1,2-dimethyl hydrazine (DMH)-induced colorectal cancer in rats model
  • as a flavanoid to investigate its protective effects against mitochondrial dysfunction on antimycin-A induced murine C2C12 skeletal muscle cells
  • as a potential endonuclease inhibitor of influenza polymerase PA subunit

Acciones bioquímicas o fisiológicas

Flavonoid glycoside found in the acai tree and globe and passion flowers. Antiviral, antimicrobial and antioxidant. Exhibits radioprotective activities.
Orientin displays neuroprotective effects against hydrogen peroxide-induced SH-SY5Y neuroblastoma cells. It exerts antioxidant, anti-inflammation, antiaging, antidepressant-like, vasodilation, vasorelaxant, and cardioprotective effects.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
MKCV4916
MKCT8309
MKCN7655
MKCL8434
MKCJ7364

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Sigma-Aldrich

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Kalaiyarasu Thangaraj et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 96, 1253-1266 (2017-12-05)
Orientin, a C-glycosyl dietary flavone profusely found in rooibos tea and passion fruit have gained much attention owing to their multiple pharmacological potentials. The present study intends to investigate the anti-proliferative and anti-inflammatory efficacy of Orientin in 1,2-dimethyl hydrazine (DMH)
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Acta neurologica Belgica, 92(1), 30-35 (1992-01-01)
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Molecules (Basel, Switzerland), 26(20) (2021-10-24)
The current study investigated the physiological effects of flavonoids found in daily consumed rooibos tea, aspalathin, isoorientin, and orientin on improving processes involved in mitochondrial function in C2C12 myotubes. To achieve this, C2C12 myotubes were exposed to a mitochondrial channel
Kit Ying Lam et al.
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Medicinal plants continue to play an important role in modern medications and healthcare as consumers generally believe that most of them cause fewer or milder adverse effects than the conventional modern medicines. In order to use the plants as a
D Marti Garin et al.
Acta orthopaedica Belgica, 58(1), 36-42 (1992-01-01)
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