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Merck

R5010

Sigma-Aldrich

Resveratrol

≥99% (HPLC)

Sinónimos:

3,4′,5-trihidroxi-trans-estilbeno, 5-[(1E)-2-(4-hidroxifenil)etenil]-1,3-bencenodiol

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About This Item

Fórmula empírica (notación de Hill):
C14H12O3
Número de CAS:
Peso molecular:
228.24
Número MDL:
Código UNSPSC:
12352205
ID de la sustancia en PubChem:
NACRES:
NA.25
En este momento no podemos mostrarle ni los precios ni la disponibilidad

origen biológico

plant root (bushy knotweed)

Nivel de calidad

Ensayo

≥99% (HPLC)

Formulario

powder

solubilidad

acetone: 50 mg/mL, clear, faintly yellow

aplicaciones

metabolomics
vitamins, nutraceuticals, and natural products

temp. de almacenamiento

−20°C

cadena SMILES

Oc1ccc(cc1)\C=C\c2cc(O)cc(O)c2

InChI

1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+

Clave InChI

LUKBXSAWLPMMSZ-OWOJBTEDSA-N

Información sobre el gen

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Aplicación

El resveratrol se ha utilizado:
  • en experimentos de atrapamiento[1]
  • para estudiar su efecto neuroprotector sobre la muerte de las células neuronales retinianas mediada por la activación, inducida por la diabetes, de la proteína cinasa II dependiente de Ca2+/calmodulina[2]
  • como un patrón en la evaluación del contenido de estilbeno en la hoja de la vid mediante fluorometría in vivo[3]

Inhibidor selectivo de de COX−1.

Acciones bioquímicas o fisiológicas

El resveratrol es una fitoalexina fenólica que se encuentra en la piel de las uvas y otras plantas. Tiene actividad antioxidante intracelular y activa la sirtuína 1(SIRT1), una desacetilasa de histonas dependiente del dinucleótido de nicotinamida y adenina (NAD+) implicada en la biogénesis mitocondrial y la intensificación del coactivador 1a del receptor activado por el proliferador g de peroxisomas (PGC-1a ) y la actividad FOXO (dominio de cabeza de tenedor [forkhead box]). Las acciones antidiabetógena, neuroprotectora y antiadipogénica del resveratrol pueden mediarse a través de la activación de la SIRT1. El resveratrol tiene acción antivírica contra el virus del herpes simple-1 (HSV1) y el HSV2. También exhibe actividades biológicas antitumorales y fitoestrogénicas.[4] Se sabe que el resveratrol prolonga la vida en muchas especies interviniendo en diversos eventos fisiológicos.[5]

Nota de preparación

Soluble en etanol, DMSO y acetona. Sólo muy ligeramente soluble en agua (3 mg/100 ml).

también adquirido normalmente con este producto

Referencia del producto
Descripción
Precios

Pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Eye Irrit. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

>392.0 °F - closed cup - (External MSDS)

Punto de inflamabilidad (°C)

> 200.0 °C - closed cup - (External MSDS)

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Certificados de análisis (COA)

Lot/Batch Number

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Visite la Librería de documentos

Resveratrol inhibits neuronal apoptosis and elevated Ca2+/calmodulin-dependent protein kinase II activity in diabetic mouse retina
Kim YH, et al.
Diabetes, 59(7), 1825-1835 (2010)
Fast and local assessment of stilbene content in grapevine leaf by in vivo fluorometry
Poutaraud A, et al.
Journal of Agricultural and Food Chemistry, 55(13), 4913-4920 (2007)
Therapeutic potential of resveratrol: the in vivo evidence
Baur JA and Sinclair DA
Nature Reviews Drug Discovery, 5(6), 493-493 (2006)
Halloysite clay nanotubes for resveratrol delivery to cancer cells
Vergaro V, et al.
Macromolecular Bioscience, 12(9), 1265-1271 (2012)
Resveratrol improves health and survival of mice on a high-calorie diet
Baur JA, et al.
Nature, 444(7117), 337-337 (2006)

Artículos

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

Questions

1–10 of 10 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What is the solubility limit in ethanol ?

    1 answer
    1. This product is tested for solubility in acetone at 50 mg/mL. It is soluble in ethanol at 50 mg/mL and in DMSO at 16 mg/mL.

      Helpful?

  4. does it expires? How long does powder last?

    1 answer
    1. This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.

      Helpful?

  5. 1- What is the iso-form (Cis or Trans) of the Resveratrol product R5010-500MG? 2- Do you have it emission spectra in 2-propanol and DMSO?

    1 answer
    1. As per the IUPAC name given, this product is a trans isoform. Unfortunately, emission spectra in 2-propanol and DMSO cannot be provided.

      Helpful?

  6. Can Resveratrol, Product R5010, be used as a treatment for human patients?

    1 answer
    1. No. Unfortunately, none of our catalog items are suitable for pharmaceutical applications.  To inquire further on our ability to provide USP material please email our SAFC Pharma group at [email protected].

      Helpful?

  7. In what applications do researchers use Resveratrol, Product R5010?

    1 answer
    1. There are numerous applications for Resveratrol.  Several references indicate that it is used as a COX-1 inhibitor and a tumor repressor.

      Helpful?

  8. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  9. How do I store Resveratrol, Product R5010, once in solution?

    1 answer
    1. A 5 mM solution of R5010 in ethanol has been found to be stable for 12 weeks when stored at 2-8°C and protected from light.Given a molecular weight of 228.24, a 5 mM solution is approximately 1.1 mg/mL.Reference: D.M. Goldberg, et al., J. Chrom. A, 708, 89-98 (1995).

      Helpful?

  10. How do I dissolve Resveratrol, Product R5010?

    1 answer
    1. We test the solubility in ethanol at a concentration of 50 mg/mL.  It is also soluble at 16 mg/mL in DMSO (with sonication). It is practically insoluble in water.

      Helpful?

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