Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

View All Documentation

MSQC8

Sigma-Aldrich

SigmaMAb Antibody Drug Conjugate (ADC) Mimic

Antibody Cysteine-Fluorophore Conjugate Standard

Sinónimos:

Antibody Drug Conjugate

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

UNSPSC Code:
12352204
NACRES:
NA.32

recombinant

expressed in CHO cells

Quality Level

200

antibody product type

primary antibodies

form

lyophilized powder

shipped in

wet ice

storage temp.

−20°C

General description

SigmaMab Antibody Drug Conjugate (ADC) Mimic, is a non-toxic drug mimic that is utilized as a standard for mass spectrometry and high performance liquid chromatography. The ADC Mimic conjugates SigmaMab (MSQC4), an IgG1 monoclonal antibody, to dansyl fluorophores via an LC-SMCC crosslinker. This dansyl-LC-SMCC attachment serves as the substitution for the toxic payload of a real ADC.

The ADC Mimic allows for safer and more consistent testing, making it the optimal product over real ADCs. It is also a more affordable product compared to real ADCs. With the help of this non-toxic product, LC-MS processes can be developed in a safer environment.

Application

Poster: Antibody Drug Conjugate Mimic Enables LC-MS Method Development Without Risk

Poster: LC-UV-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC-Mimic

Poster: LC-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC Mimic

¿No encuentra el producto adecuado?  

Pruebe nuestro Herramienta de selección de productos.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Craig Jakes et al.
Analytical chemistry, 93(40), 13505-13512 (2021-09-30)
Monoclonal antibodies (mAbs) and related products undergo a wide range of modifications, many of which can often be directly associated to culture conditions during upstream processing. Ideally, such conditions should be monitored and fine-tuned based on real-time or close to

Protocolos

LC-UV-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC-Mimic

SigmaMab Antibody Drug Conjugate Mimic, is a non-toxic drug mimic utilized as a standard for mass spectrometry and high performance liquid chromatography.

Antibody Drug Conjugate Mimic Enables LC-MS Method Development Without Risk

Here we show how LC and MS methods may be optimized using a non-toxic surrogate of the ADC, an “ADC-mimic”, that behaves very similarly to the Cys-linked ADC Adcetris (Seattle Genetics).

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico