902675

BocNH-PEG₆-acid

• Sinónimos: 2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid, Boc-NH-PEG6-CH₂COOH
• Fórmula empírica (notación de Hill): C₁₉H₃₇NO₁₀
• Número de CAS: 391684-36-9
• Peso molecular: 439.50
• Número MDL: MFCD30489670
• Código UNSPSC: 12352106
• NACRES: NA.22

Propiedades

• Formulario: liquid
• idoneidad de la reacción: reagent type: linker
• índice de refracción: n/D 1.4657
• grupo funcional: Boc; amine; carboxylic acid
• temp. de almacenamiento: −20°C
• cadena SMILES: OC(COCCOCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
• InChI: 1S/C19H37NO10/c1-19(2,3)30-18(23)20-4-5-24-6-7-25-8-9-26-10-11-27-12-13-28-14-15-29-16-17(21)22/h4-16H2,1-3H3,(H,20,23)(H,21,22)
• Clave InChI: ZKCDWMFMVAYYED-UHFFFAOYSA-N

Descripción

Aplicación

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG₆-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Otras notas

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Información legal

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable