1349706

Isoniazid

United States Pharmacopeia (USP) Reference Standard

• Synonyme(s) : 4-Pyridinecarboxylic acid hydrazide, INH, Isonicotinic acid hydrazide, Isonicotinic hydrazide
• Formule empirique (notation de Hill): C₆H₇N₃O
• Numéro CAS: 54-85-3
• Poids moléculaire : 137.14
• Numéro Beilstein : 119374
• Numéro MDL: MFCD00006426
• Code UNSPSC : 41116107
• ID de substance PubChem : 329750199
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: pharmaceutical primary standard
• Famille d'API: isoniazid
• Fabricant/nom de marque: USP
• Pf: 171-173 °C (lit.)
• Application(s): pharmaceutical (small molecule)
• Format: neat
• Température de stockage: 2-8°C
• Chaîne SMILES: NNC(=O)c1ccncc1
• InChI: 1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
• Clé InChI: QRXWMOHMRWLFEY-UHFFFAOYSA-N

Description

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Isoniazid USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Isoniazid Tablets
• Isoniazid Injection
• Isoniazid Oral Solution
• Rifampin and Isoniazid Capsules
• Rifampin, Isoniazid, and Pyrazinamide Tablets
• Rifampin, Isoniazid, Pyrazinamide, and Ethambutol Hydrochloride Tablets

Actions biochimiques/physiologiques

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315
• Conseils de prudence: P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364
• Classification des risques: Acute Tox. 4 Oral - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3