1205003

Diltiazem hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Synonyme(s) : (+)-cis-Diltiazem hydrochloride, (2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride, CRD-401
• Formule empirique (notation de Hill): C₂₂H₂₆N₂O₄S · HCl
• Numéro CAS: 33286-22-5
• Poids moléculaire : 450.98
• Numéro Beilstein : 4228706
• Numéro MDL: MFCD00069252
• Code UNSPSC : 41116107
• ID de substance PubChem : 329749607
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: pharmaceutical primary standard
• Famille d'API: diltiazem
• Fabricant/nom de marque: USP
• Application(s): pharmaceutical (small molecule)
• Format: neat
• Chaîne SMILES: Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O
• InChI: 1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1
• Clé InChI: HDRXZJPWHTXQRI-BHDTVMLSSA-N
• Informations sur le gène: human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

Description

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

• Exploring the Effectiveness of Carboxymethylated and Crosslinked Albizia procera Gum in Diltiazem Hydrochloride Matrix Tablets: A Comparative Analysis. This study investigates the potential of carboxymethylated and crosslinked Albizia procera gum for use in sustained-release matrix tablets containing Diltiazem hydrochloride, highlighting its viability in pharmaceutical applications (Mukherjee S, Khanam J, 2024).


• Dietary gallic acid as an antioxidant: A review of its food industry applications, health benefits, bioavailability, nano-delivery systems, and drug interactions. While primarily focused on gallic acid, this review mentions Diltiazem hydrochloride in the context of drug interactions and its implications in food safety and health (Xiang Z et al., 2024).


• Dual stimuli-responsive and sustained drug delivery NanoSensoGel formulation for prevention of cisplatin-induced ototoxicity. This research presents a novel NanoSensoGel that could be adapted for Diltiazem hydrochloride, enhancing drug delivery efficiency in clinical settings (Thakur NS et al., 2024).


• A novel potentiometric sensor based on ZnO decorated polyaniline/coal nanocomposite for diltiazem determination. This study develops a new sensor for the precise measurement of Diltiazem levels in pharmaceutical formulations, which is crucial for quality control and regulatory compliance (El Sayed GA et al., 2023).


• The Effect of Topical Nifedipine versus Diltiazem on the Acute Anal Fissure: A Randomized Clinical Trial. This clinical trial evaluates the effectiveness of Diltiazem hydrochloride in treating acute anal fissures, providing evidence of its beneficial applications in proctological disorders (Momayez Sanat Z et al., 2023).

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P301 + P312 + P330
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable