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Key Documents

SMB00704

Sigma-Aldrich

Lipopolysaccharides from Proteus mirabilis

purified by phenol extraction

Synonyme(s) :

LPS

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About This Item

Numéro CE :
297-473-0
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Source biologique

bacterial (Proteus mirabilis)

Niveau de qualité

200

Forme

lyophilized powder

Produit purifié par

phenol extraction

Impuretés

<3.00% protein (Lowry-TCA)

Couleur

white to faint yellow

Solubilité

water: 0.90-1.10 mg/mL, slightly hazy to hazy, colorless to light yellow

Conditions d'expédition

ambient

Température de stockage

2-8°C

Description générale

Lipopolysaccharides (LPS′s) are complex glycolipids that are characteristic components of the cell wall of Gram-negative bacteria. They consist of a lipid A moiety linked to an antigenic O-polysaccharide.
Proteus mirabilis is a Gram-negative facultative anaerobic rod-shaped bacterium. Bacteria of the genus Proteus of the family Enterobacteriaceae are opportunistic human pathogens responsible for wound and burn infections as well as skin, eye, ear, nose, throat, urinary tract, and gastrointestinal infections and bacteremias.

Application


  • Lipopolysaccharide structure modulates cationic biocide susceptibility and crystalline biofilm formation in Proteus mirabilis.: The study explores how variations in lipopolysaccharide structure affect the susceptibility of Proteus mirabilis to biocides and its ability to form crystalline biofilms, informing strategies to combat biofilm-associated infections (Clarke et al., 2023).

Actions biochimiques/physiologiques

Lipopolysaccharide (LPS) and its lipid A moiety stimulate cells of the innate immune system by the toll-like receptor 4 (TLR4), a member of the toll-like receptor protein family, which recognizes common pathogen-associated molecular patterns (PAMPs). Lipid A plays a role in the biological properties attributed to endotoxic LPS. LPS is a highly immunogenic antigen that has the ability to enhance immune responses.The outer-membrane lipopolysaccharide is considered an important virulence factor of Proteus. It has been suggested that the immunological response against P. mirabilis, LPS might play a role in rheumatoid arthritis. A possible correlation between the abundance of P. mirabilis in the intestine and obesity was suggested recently. The purified LPS from P. mirabilis OXK is used in the Weil-Felix test for the diagnosis of rickettsiosis (scrub typhus) caused by the bacterium Orientia (Rickettsia) tsutsugamushi.

Notes préparatoires

Soluble in water and cell culture medium DMEM (1 mg/mL) yielding a clear to slightly hazy solution.

Autres remarques

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Les clients ont également consulté

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Lipopolysaccharides from Escherichia coli O111:B4 purified by phenol extraction

Sigma-Aldrich

L2630

Lipopolysaccharides from Escherichia coli O111:B4

Distribution of core oligosaccharide types in lipopolysaccharides from Escherichia coli.
Amor K, et al.
Infection and Immunity, 68(3), 1116-1124 (2000)
Analysis of Lipopolysaccharides of Gram-Negative Bacteria
Mayer H, Tharanathan RN, Weckesser J
Methods in Microbiology, 18, 157-207 (1985)
Novel adjuvants & delivery vehicles for vaccines development: a road ahead.
Mohan T, et al.
The Indian Journal of Medical Research, 138(5), 779-795 (2013)
Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica.
Heinrichs D E, et al.
Molecular Microbiology, 30(2), 221-232 (1998)
A S Swierzko et al.
Biochemistry. Biokhimiia, 62(1), 21-27 (1997-01-01)
Sugar analysis and 1H- and 13C-NMR spectroscopic studies showed that various strains of Proteus mirabilis OXK used as antigens in the Weil-Felix test for serodiagnosis of rickettsiosis (scrub typhus) produce lipopolysaccharides (LPSs) with the same O-specific polysaccharide chain having the
Afficher tous les articles scientifiques apparentés

Articles

Lipopolysaccharides for Research – Structure, Function & Applications

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

Lipopolysaccharides for Research – Structure, Function & Applications

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

Lipopolysaccharides for Research – Structure, Function & Applications

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

Lipopolysaccharides for Research – Structure, Function & Applications

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

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