S0802
Stearoyl coenzyme A lithium salt
≥90%
Synonyme(s) :
n-Octadecanoyl Coenzyme A
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About This Item
Formule empirique (notation de Hill):
C39H70N7O17P3S
Numéro CAS:
Poids moléculaire :
1034.00
Code UNSPSC :
41106305
Nomenclature NACRES :
NA.51
Produits recommandés
Application
Coenzyme A functions as an acyl group carrier, acetyl-CoA. Stearoyl CoA is a saturated fatty acid metabolite involved in polyunsaturated fatty acid synthesis and the PPAR signaling pathway. Stearoyl CoA is used to study the specificity and kinetics of stearoyl-CoA desaturase(s) which lead to the formation of monounsaturated fatty acids.
Stearoyl coenzyme A lithium salt may be used as a substrate in the stearoyl-CoA desaturase assay in microsomes.
Actions biochimiques/physiologiques
Stearoyl CoA is a saturated fatty acid metabolite involved in polyunsaturated fatty acid synthesis and the PPAR signaling pathway. Stearoyl CoA is a substrate for the enzyme stearoyl-CoA desaturase. Stearoyl CoA desaturation is the crucial step in unsaturated fatty acid biosynthesis. Stearoyl CoA is converted to oleoyl-CoA by stearoyl-CoA desaturase.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Les clients ont également consulté
Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy
Roongta UV, et al.
Molecular Cancer Research, 9(11), 1551-1561 (2011)
M Minville-Walz et al.
Genes & nutrition, 7(2), 209-216 (2011-11-08)
Consumption of trans fatty acids is positively correlated with cardiovascular diseases and with atherogenic risk factors. Trans fatty acids might play their atherogenic effects through lipid metabolism alteration of vascular cells. Accumulation of lipids in vascular smooth muscle cells is
The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1
Miyazaki M, et al.
The Journal of Biological Chemistry, 275(39), 30132-30138 (2000)
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
Ntambi JM, et al.
Proceedings of the National Academy of Sciences of the USA, 99(17), 11482-11486 (2002)
Eunha Kim et al.
European journal of pharmacology, 672(1-3), 38-44 (2011-10-06)
Stearoyl-CoA desaturase1 (SCD1) whole body deficiency protects mice from diet-induced obesity. However the specific mechanism of how SCD1 deficiency protects mice from obesity is not clear yet. To understand the tissue-specific role of SCD1 in energy homeostasis, we investigated the
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