R101

Ranitidine hydrochloride

solid

• Formule empirique (notation de Hill): C₁₃H₂₂N₄O₃S · HCl
• Numéro CAS: 66357-59-3
• Poids moléculaire : 350.86
• Numéro CE : 266-333-0
• Numéro MDL: MFCD00069339
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277803
• Nomenclature NACRES : NA.77

Propriétés

• Forme: solid
• Niveau de qualité: 200
• Couleur: tan
• Solubilité: H₂O: 1.8 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 7.0 mg/mL
• Auteur: GlaxoSmithKline
• Chaîne SMILES: Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O
• InChI: 1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;
• Clé InChI: GGWBHVILAJZWKJ-CHHCPSLASA-N
• Informations sur le gène: human ... HRH2(3274)

Description

Application

Ranitidine hydrochloride has been used as a reference compound for the development and validation of parallel artificial membrane permeability assay (PAMPA).

Actions biochimiques/physiologiques

Ranitidine is mainly used to treat gastrointestinal impairment instigated by non-steroidal anti-inflammatory drugs (NSAIDs).

H₂ histamine receptor antagonist; anti-ulcer agent.

Caractéristiques et avantages

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H315,H317,H319,H334,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)