26454

Magnesium stearate

puriss., meets analytical specification of Ph. Eur., BP, ≥90% stearic and palmitic acid basis, ≥40% stearic acid basis (GC), 4.0-5.0% Mg basis (calc on dry sub.)

• Synonyme(s) : Stearic acid magnesium salt
• Formule linéaire : [CH₃(CH₂)₁₆CO₂]₂Mg
• Numéro CAS: 557-04-0
• Poids moléculaire : 591.24
• Numéro Beilstein : 3919702
• Numéro CE : 209-150-3
• Numéro MDL: MFCD00036391
• Code UNSPSC : 12352106
• ID de substance PubChem : 57648176
• Nomenclature NACRES : NA.22

Propriétés

• Qualité: puriss.; meets analytical specification of Ph. Eur., BP
• Pureté: ≥40% stearic acid basis (GC); ≥90% stearic and palmitic acid basis; 4.0-5.0% Mg basis (calc on dry sub.)
• Impuretés: acidity or alkalinity, complies; microbiological impurity, in accordance; residual solvents, complies
• Perte: ≤6.0% loss on drying, 105 °C
• Pf: 200 °C (lit.)
• Indice d'acide: 195‑210(fatty acid)
• Solubilité: alcohol: insoluble; diethyl ether: insoluble; water: insoluble
• Traces d'anions: chloride (Cl^-): ≤1000 mg/kg; sulfate (SO₄^2-): ≤5000 mg/kg
• Traces de cations: Cd: ≤3 mg/kg; Ni: ≤5 mg/kg; Pb: ≤10 mg/kg
• Adéquation: in accordance for fatty acid composition; passes test for identity
• Application(s): pharmaceutical (small molecule)
• Chaîne SMILES: CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC
• InChI: 1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
• Clé InChI: HQKMJHAJHXVSDF-UHFFFAOYSA-L

Description

Application

Magnesium stearate has been used as a tablet and capsule lubricant. It has also been used for preparing microcapsules.

Actions biochimiques/physiologiques

Magnesium stearate is the magnesium salt of stearic acid that possess lubricating properties and hence prevents ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets. Dry coating of drugs with magnesium stearate leads to flow improvement, flow-aid and lubrication effects, tabletability as well as non-inhibited dissolution rate.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves