PZ0178

PHA 767491 hydrochloride

≥98% (HPLC)

• Synonyme(s) : 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride, 2-Pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one hydrochloride, PHA-00767491 hydrochloride
• Formule empirique (notation de Hill): C₁₂H₁₁N₃O · xHCl
• Numéro CAS: 845538-12-7
• Poids moléculaire : 213.24 (free base basis)
• Numéro MDL: MFCD11519962
• Code UNSPSC : 51111800
• ID de substance PubChem : 329823752
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: off-white to yellow
• Solubilité: H₂O: >25 mg/mL
• Chaîne SMILES: Cl.O=C1NCCc2[nH]c(cc12)-c3ccncc3
• InChI: 1S/C12H11N3O.ClH/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12;/h1-2,4-5,7,15H,3,6H2,(H,14,16);1H
• Clé InChI: IMVNFURYBZMFDZ-UHFFFAOYSA-N

Description

Application

PHA 767491 hydrochloride has been used to study its effect on estrogen-induced DNA damage. It has also been used in western blot analysis and to study the S9.6 nuclear signal in HeLa cells.

Actions biochimiques/physiologiques

PHA 767491 serves as a potential anticancer drug. It shows an ameliorating effect against acute myeloid leukemia, colon and breast cancer models. PHA 767491 possesses anti proliferating and apoptotic effect.

PHA-767491 is a potent and selective ATP-competitive dual inhibitor cdc7/cdk9. PHA-767491 blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable