N0636

Nicotinamide

BioReagent, suitable for cell culture, suitable for insect cell culture

• Synonyme(s) : Acide nicotinique amide, Acide pyridine-3-carboxylique amide, Vitamine PP, Vitamine B₃
• Formule empirique (notation de Hill): C₆H₆N₂O
• Numéro CAS: 98-92-0
• Poids moléculaire : 122.12
• Numéro Beilstein : 383619
• Numéro CE : 202-713-4
• Numéro MDL: MFCD00006395
• Code UNSPSC : 12352205
• ID de substance PubChem : 24897434
• Nomenclature NACRES : NA.75

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Gamme de produits: BioReagent
• Pureté: ≥98% (HPLC)
• Forme: powder
• Poids mol.: M_w 122.12 g/mol
• Technique(s): cell culture | insect: suitable; cell culture | mammalian: suitable
• Couleur: white
• Pf: 128-131 °C (lit.)
• Solubilité: water: soluble 50 mg/mL, clear, colorless
• Chaîne SMILES: NC(=O)c1cccnc1
• InChI: 1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
• Clé InChI: DFPAKSUCGFBDDF-UHFFFAOYSA-N
• Informations sur le gène: human ... PARP1(142) , SIRT2(22933)

Description

Description générale

Nicotinamide (NAM) belongs to vitamin B family and is the amide form of vitamin B3. NAM is present in food and is a constituent of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Tryptophan is the precursor for NAM synthesis in liver. NAM controls cell metabolism, redox reactions, mitochondrial functionsand energy generation. It promotes natural killer cells proliferation and survival. NAM confers neuroprotection and promotes neuronal maturation. It has the ability to cross the blood-brain barrier and may provide protection in ischaemic stroke and traumatic brain injury. NAM may elicit therapeutic benefits in Alzheimer′s, Parkinson′s, and Huntington′s diseases.

Application

Nicotinamide has been used as a medium supplement in organoid culture of intestinal stem cells, esophageal squamous cell carcinomas(ESCC), pancreatic cancer organoids and pancreatic progenitor induction.

Actions biochimiques/physiologiques

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H319
• Conseils de prudence: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classification des risques: Eye Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 302.0 °F - closed cup
• Point d'éclair (°C): 150 °C - closed cup
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves