G9020

Gastrin I human

≥95% (HPLC), powder

• Synonyme(s) : Gastrin I, heptadecapeptide, HG-17, Little gastrin I, human, [18-Pyroglutamic acid]big gastrin I-(18-34)-peptide amide, human, [pGlu¹⁸]-Big gastrin I fragment 18-34 amide
• Formule empirique (notation de Hill): C₉₇H₁₂₄N₂₀O₃₁S
• Numéro CAS: 10047-33-3
• Poids moléculaire : 2098.20
• Numéro CE : 233-157-0
• Numéro MDL: MFCD00076500
• Code UNSPSC : 12352200
• ID de substance PubChem : 24895361
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human
• Niveau de qualité: 200
• Pureté: ≥95% (HPLC)
• Forme: powder
• Poids mol.: 2098.20
• Conditions de stockage: (Keep container tightly closed in a dry and well-ventilated place)
• Concentration: ≤100%
• Technique(s): protein expression: suitable
• Solubilité: water: 1.00-1.04 mg/mL, clear, colorless
• Numéro d'accès UniProt: P01350
• Température de stockage: −20°C
• Chaîne SMILES: CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@@H]6CCCN6C(=O)CNC(=O)[C@@H]7CCC(=O)N7)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc8ccccc8)C(N)=O
• InChI: 1S/C97H124N20O31S/c1-49(2)39-68(114-95(146)71(43-54-46-100-59-18-11-9-16-57(54)59)116-97(148)73-19-12-37-117(73)76(121)48-102-85(136)60-24-30-74(119)104-60)93(144)110-65(29-35-81(130)131)91(142)109-64(28-34-80(128)129)90(141)108-63(27-33-79(126)127)89(140)107-62(26-32-78(124)125)88(139)106-61(25-31-77(122)123)87(138)103-50(3)84(135)113-69(41-52-20-22-55(118)23-21-52)86(137)101-47-75(120)105-70(42-53-45-99-58-17-10-8-15-56(53)58)94(145)111-66(36-38-149-4)92(143)115-72(44-82(132)133)96(147)112-67(83(98)134)40-51-13-6-5-7-14-51/h5-11,13-18,20-23,45-46,49-50,60-73,99-100,118H,12,19,24-44,47-48H2,1-4H3,(H2,98,134)(H,101,137)(H,102,136)(H,103,138)(H,104,119)(H,105,120)(H,106,139)(H,107,140)(H,108,141)(H,109,142)(H,110,144)(H,111,145)(H,112,147)(H,113,135)(H,114,146)(H,115,143)(H,116,148)(H,122,123)(H,124,125)(H,126,127)(H,128,129)(H,130,131)(H,132,133)/t50-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-/m0/s1
• Clé InChI: GKDWRERMBNGKCZ-RNXBIMIWSA-N
• Informations sur le gène: human ... GAST(2520)

Description

Amino Acid Sequence

Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2

Description générale

Research area: Cell Signaling

The GAST gene is mapped to human chromosome 17q21. Gastrin is a linear peptide. It is a gastrointestinal hormone, produced by G cells in the stomach.

Application

Gastrin I human has been used:

• to treat AGS stably transfected with gastrin receptor/cholecystokinin receptor 2 (CCK2R) (AGS-GR) cells to study the expression and secretion of clusterin (CLU) in human gastric cancer cells
• as a component of growth medium for culturing mouse normal esophageal epithelial organoid (mNEEO)
• as a supplement in basal culture media to use for organoid-like cultures
• as a molecular weight marker to calibrate superdex^® 30 columns.

Actions biochimiques/physiologiques

Gastrin plays a major role in parietal cell function, gastric epithelial cell multiplication, and differentiation. It acts as a modulator in maintaining and organizing gastric mucosa. It is produced in the stomach and stimulates gastric acid secretion. Gastrin is an important growth factor for the gastrointestinal tract. Gastrin binds with high affinity to the cholecystokinin B receptor (CCKBR) that belongs to the family of G-protein coupled receptors. It induces islet differentiation in the pancreas.

Autres remarques

Lyophilized from 0.1% TFA in H2O

Informations légales

Superdex is a registered trademark of Cytiva

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)