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Key Documents

BP460

Nicotinamide

British Pharmacopoeia (BP) Reference Standard

Synonyme(s) :

Acide nicotinique amide, Acide pyridine-3-carboxylique amide, Vitamine PP, Vitamine B3

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About This Item

Formule empirique (notation de Hill):
C6H6N2O
Numéro CAS:
Poids moléculaire :
122.12
Numéro Beilstein :
383619
Numéro MDL:
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Agence

BP

Famille d'API

nicotinamide

Forme

solid

Fabricant/nom de marque

BP

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Pf

128-131 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

−20°C

Chaîne SMILES 

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

Clé InChI

DFPAKSUCGFBDDF-UHFFFAOYSA-N

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Nicotinamide, a member of the family of water-soluble B vitamins, is generally produced from nicotinic acid (vitamin B3). It is often present in food products. It has been reported to have been effective in the treatment of pellagra, psoriasis, schizophrenia, and type I diabetes. It is also shown to possess anti-inflammatory activity.

Application

Nicotinamide BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Vitamins B and C Injection
  • Nicorandil Tablets
  • Actions biochimiques/physiologiques

    Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

    Conditionnement

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Autres remarques

    Sales restrictions may apply.

    Pictogrammes

    Exclamation mark

    Mention d'avertissement

    Warning

    Mentions de danger

    Classification des risques

    Eye Irrit. 2

    Code de la classe de stockage

    11 - Combustible Solids

    Classe de danger pour l'eau (WGK)

    WGK 1

    Point d'éclair (°F)

    302.0 °F - closed cup

    Point d'éclair (°C)

    150 °C - closed cup


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    Les clients ont également consulté

    Evaluation of analytical tools and multivariate methods for quantification of co-former crystals in ibuprofen-nicotinamide co-crystals
    Soares FLF and Carneiro RL
    Journal of Pharmaceutical and Biomedical Analysis, 89, 166-175 (2014)
    Development of a validated HPLC method for the determination of B-complex vitamins in pharmaceuticals and biological fluids after solid phase extraction
    Chatzimichalakis PF, et al.
    Journal of Separation Science, 27(14), 1181-1188 (2004)
    Nicotinamide
    European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
    European pharmacopoeia, 14(4), 3145-3146 (2017)
    Simultaneous determination and classification of riboflavin, thiamine, nicotinamide and pyridoxine in pharmaceutical formulations, by UV-visible spectrophotometry and multivariate analysis
    Lopez-de-Alba LP, et al.
    Journal of the Brazilian Chemical Society, 17(4), 715-722 (2006)
    Youdan Shi et al.
    International immunopharmacology, 14(4), 530-537 (2012-10-13)
    Nicotinamide (NAM), the amide form of vitamin B3, is involved in a wide range of biological processes. Recent evidence revealed the anti-inflammatory and anti-oxidant properties of NAM and suggests it may be used as a novel strategy in the prevention

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