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H0536

Sigma-Aldrich

Hepatocyte Growth Factor Receptor (c-Met)/Fc Chimera human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonyme(s) :

HGF Receptor (c-Met)

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About This Item

Numéro MDL:
MFCD01867051
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

human

Niveau de qualité

100

Produit recombinant

expressed in NSO cells

Pureté

>95% (SDS-PAGE)

Forme

lyophilized powder

Puissance

0.1-5 ng/mL

Poids mol.

calculated mol wt 129 kDa

Conditionnement

pkg of 100 μg

Conditions de stockage

avoid repeated freeze/thaw cycles

Impuretés

endotoxin, tested

Numéro d'accès UniProt

P08581

Température de stockage

−20°C

Informations sur le gène

human ... MET(4233)

Actions biochimiques/physiologiques

Heterodimeric transmembrane glycoprotein with binding capacity for c-Met. Activation of this receptor has been correlated with induction of the Ras pathway.

Autres remarques

Extracellular domain of c-Met fused to the C-terminal 6X histidine-tagged Fc region of human IgG1.

Forme physique

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing 5 mg bovine serum albumin.

Remarque sur l'analyse

The biological activity is measured by its ability to bind human HGF.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Yaroslava M Chalenko et al.
International journal of molecular sciences, 24(8) (2023-04-28)
Listeria monocytogenes virulence factor InlB specifically interacts with the receptors c-Met and gC1q-R. Both receptors are present in non-professional and professional phagocytes, including macrophages. Phylogenetically defined InlB isoforms differently support invasion into non-professional phagocytes. This work deals with the effects
M Park et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(18), 6379-6383 (1987-09-01)
We isolated overlapping cDNA clones corresponding to the major MET protooncogene transcript. The cDNA nucleotide sequence contained an open reading frame of 1408 amino acids with features characteristic of the tyrosine kinase family of growth factor receptors. These features include
Egor V Kalinin et al.
Drug development research, 82(1), 123-132 (2020-08-25)
Hepatocyte growth factor (HGF) is central to liver regeneration. The Internalin B (InlB) protein is a virulence factor produced by the pathogenic bacterium Listeria monocytogenes. InlB is known to mimic HGF activity by interacting with the HGF receptor (HGFR) and
Xin Li et al.
Frontiers in cell and developmental biology, 9, 661122-661122 (2021-05-04)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with minimally effective treatments, highlighting the importance of developing novel biomarkers and therapeutic targets. Here, we disclosed the mechanisms that leukocyte cell-derived chemotaxin-2 (LECT2) modulates PDAC development using in

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