G8134

Gallamine triethiodide

≥98% (TLC), powder, muscarinic receptor antagonist

• Formule empirique (notation de Hill): C₃₀H₆₀I₃N₃O₃
• Numéro CAS: 65-29-2
• Poids moléculaire : 891.53
• Numéro CE : 200-605-1
• Numéro MDL: MFCD00011832
• Code UNSPSC : 12352116
• ID de substance PubChem : 24277837
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Pureté: ≥98% (TLC)
• Forme: powder
• Pf: 235 °C (dec.) (lit.)
• Solubilité: H₂O: 100 mg/mL; ethanol: soluble
• Température de stockage: 2-8°C
• Chaîne SMILES: [I-].[I-].[I-].CC[N+](CC)(CC)CCOc1cccc(OCC[N+](CC)(CC)CC)c1OCC[N+](CC)(CC)CC
• InChI: 1S/C30H60N3O3.3HI/c1-10-31(11-2,12-3)22-25-34-28-20-19-21-29(35-26-23-32(13-4,14-5)15-6)30(28)36-27-24-33(16-7,17-8)18-9;;;/h19-21H,10-18,22-27H2,1-9H3;3*1H/q+3;;;/p-3
• Clé InChI: REEUVFCVXKWOFE-UHFFFAOYSA-K
• Informations sur le gène: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133) , CHRNA1(1134) , CHRNB1(1140) , CHRND(1144) , CHRNE(1145) , CHRNG(1146)

Description

Application

Gallamine triethiodide has been used:

• as a relaxant for measuring spinal trigeminal nucleus recordings from single neurons.
• as an antagonist in neuroblastoma cells as M2 receptor
• to reduce eye movement during retinal surgery in rat

Actions biochimiques/physiologiques

Gallamine triethiodide has anti-muscarinic effect. It is a competitive antagonist for the muscarinic receptor. Gallamine is regarded as neuromuscular blocking agent.

Muscle relaxant; allosteric muscarinic receptor antagonist with an order of potency of M₂ > M₁ = M₄ > M₃ = M₅. Ligand for the peripheral anionic binding site of acetylcholinesterase.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Attention

Hygroscopic

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves