A0257

Atropine sulfate salt monohydrate

≥97% (TLC), crystalline, cholinergic receptor antagonist

• Synonyme(s) : α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, Tropine tropate
• Formule linéaire : (C₁₇H₂₃NO₃)₂ · H₂SO₄ · H₂O
• Numéro CAS: 5908-99-6
• Poids moléculaire : 694.83
• Numéro Beilstein : 6109275
• Numéro CE : 200-235-0
• Numéro MDL: MFCD00074815
• Code UNSPSC : 12352210
• ID de substance PubChem : 57653815
• Nomenclature NACRES : NA.32

Propriétés

• product name: Atropine sulfate salt monohydrate, ≥97% (TLC), crystalline
• Niveau de qualité: 200
• Pureté: ≥97% (TLC)
• Forme: crystalline
• Couleur: white
• Pf: 189-192 °C (A) (lit.)
• Solubilité: H₂O: 2.5 g/mL (stable for several days at 4 °C.); ethanol: 200 mg/mL (stable for several days at 4 °C.); glycerol: 400 mg/mL (stable for several days at 4 °C.)
• Chaîne SMILES: O.OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@H]5CC[C@@H]4C[C@@H](C5)OC(=O)C(CO)c6ccccc6
• InChI: 1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;
• Clé InChI: JPKKQJKQTPNWTR-CHYDPLAESA-N
• Informations sur le gène: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

Description

Description générale

Atropine is isolated from Atropa belladonna, Datura stramonium and Mandragora officinarum. It is a tertiary amine, which acts as a cholinergic receptor antagonist.

Application

Atropine sulfate salt hydrate has been used:

• to assay specific binding of high-affinity 3-quinuclidinyl benzilate-3H ([³H]QNB) to the muscarinic acetylcholine receptor (mAChR)
• to block the recovery phase of the aldicarb (Ald) response
• as an analyte for liquid chromatography with tandem mass spectrometry (LC-MS/MS)
• as a mAChR antagonist to block acetylcholine receptor

Actions biochimiques/physiologiques

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H300 + H330
• Conseils de prudence: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Classification des risques: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges