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C0780

Sigma-Aldrich

Creatine

suitable for cell culture

Synonyme(s) :

(α-Methylguanido)acetic acid, N-Amidinosarcosine

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About This Item

Formule linéaire :
H2NC(=NH)N(CH3)CH2CO2H
Numéro CAS:
57-00-1
Poids moléculaire :
131.13
Numéro Beilstein :
907175
Numéro CE :
200-306-6
Numéro MDL:
MFCD00004282
Code UNSPSC :
12352209
ID de substance PubChem :
24892273
Nomenclature NACRES :
NA.26

product name

Creatine, anhydrous

Qualité

anhydrous

Niveau de qualité

200

Forme

powder

Technique(s)

cell culture | mammalian: suitable

Couleur

white

Chaîne SMILES 

CN(CC(O)=O)C(N)=N

InChI

1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)

Clé InChI

CVSVTCORWBXHQV-UHFFFAOYSA-N

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Application

Creatine (Cr) and phosphocreatine (PCr) are involved with rapid ATP production primarily in skeletal muscle tissue via the action of creatine kinase(s). Creatine may be used as a supplement to study its uptake mechanism and metabolism of action.

Actions biochimiques/physiologiques

Creatine is a nitrogenous compound that acts as a high-energy reservoir for the rapid regeneration of ATP. Approximately 95% of creatine is found in skeletal muscle, primarily as phosphocreatine. Creatine can be acquired through dietary consumption or formed from L-arginine, glycine, and L-methionine in a multi-step reaction that occurs in the kidneys and liver. Creatine is then transported to muscle tissue. Creatine supplementation is used for the enhancement of sports performance, primarily by increasing muscle mass. Creatine is also being investigated as a treatment of neuromuscular diseases, where it may aid in neuroprotection and by improving the cellular bioenergetic state.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Creatinine United States Pharmacopeia (USP) Reference Standard

USP

1150353

Creatinine

L-Carnitine hydrochloride synthetic, ≥98%

Sigma-Aldrich

C0283

L-Carnitine hydrochloride

Creatine-(methyl-d3) monohydrate 98 atom % D

Sigma-Aldrich

616249

Creatine-(methyl-d3) monohydrate

Creatininase from microorganisms lyophilized powder, 100-300 units/mg protein

Sigma-Aldrich

C3172

Creatininase from microorganisms

Subrata Patra et al.
Amino acids, 42(6), 2319-2330 (2011-07-20)
The creatine/creatine kinase (CK) system plays a key role in cellular energy buffering and transport. In vertebrates, CK has four isoforms expressed in a tissue-specific manner. In the process of creatine biosynthesis several other important metabolites are formed. The anticancer
Philippe Généreux et al.
Journal of the American College of Cardiology, 65(6), 533-543 (2015-02-14)
Bifurcation lesions are frequent among patients with symptomatic coronary disease treated by percutaneous coronary intervention. Current evidence recommends a conservative (provisional) approach when treating the side branch (SB). The TRYTON (Prospective, Single Blind, Randomized Controlled Study to Evaluate the Safety
Lucas Lindeboom et al.
The Journal of clinical investigation, 124(11), 4915-4925 (2014-10-02)
Animal models suggest that acetylcarnitine production is essential for maintaining metabolic flexibility and insulin sensitivity. Because current methods to detect acetylcarnitine involve biopsy of the tissue of interest, noninvasive alternatives to measure acetylcarnitine concentrations could facilitate our understanding of its
Dan Atar et al.
European heart journal, 36(2), 112-119 (2014-09-03)
The MITOCARE study evaluated the efficacy and safety of TRO40303 for the reduction of reperfusion injury in patients undergoing revascularization for ST-elevation myocardial infarction (STEMI). Patients presenting with STEMI within 6 h of the onset of pain randomly received TRO40303
Gilles Montalescot et al.
Journal of the American College of Cardiology, 64(24), 2563-2571 (2014-12-20)
After percutaneous coronary intervention (PCI) for non-ST-segment elevation myocardial infarction (NSTEMI), treatment with a P2Y12 antagonist with aspirin is recommended for 1 year. The oral P2Y12 antagonists ticagrelor and prasugrel have higher recommendations than clopidogrel, but it is unknown if
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